RIPK2, receptor interacting serine/threonine kinase 2

RIPK2, receptor interacting serine/threonine kinase 2

• This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein contains a C-terminal caspase activation and recruitment domain (CARD), and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of NF-kappaB and inducer of apoptosis in response to various stimuli. [provided by RefSeq, Jul 2008]

• Gene Synonyms (receptor-interacting serine/threonine-protein kinase 2, CARD-carrying kinase, CARD-containing IL-1 beta ICE-kinase, CARD-containing interleukin-1 beta-converting enzyme (ICE)-associated kinase, RIP-2, growth-inhibiting gene 30, receptor-interacting protein (RIP)-like interacting caspase-like apoptosis regulatory protein (CLARP) kinase, receptor-interacting protein 2, tyrosine-protein kinase RIPK2, CARD3, CARDIAK, CCK, GIG30, RICK, RIP2,)
• NCBI Gene ID: 8767
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O43353
  UNIPROT ID#>>A0A0S2Z4Z8
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

receptor interacting serine/threonine kinase 2 interacts with:

• BCL10 immune signaling adaptor
  CASP8 and FADD like apoptosis regulator
  caspase 12 (gene/pseudogene)
  caspase recruitment domain family member 16
  caspase recruitment domain family member 6
  centrosomal protein 43
  leucine rich repeat kinase 2
  lysine demethylase 3A
  mitochondrial antiviral signaling protein
  N-acetyltransferase 16 (putative)
  nuclear RNA export factor 1
  nucleotide binding oligomerization domain containing 1
  nucleotide binding oligomerization domain containing 2
  pellino E3 ubiquitin protein ligase family member 3
  potassium channel tetramerization domain containing 12
  prohibitin 2
  receptor interacting serine/threonine kinase 2
  ring finger protein 31
  SMAD specific E3 ubiquitin protein ligase 1
  TGF-beta activated kinase 1 (MAP3K7) binding protein 1
  TGF-beta activated kinase 1 (MAP3K7) binding protein 2
  TNF receptor associated factor 4
  tripartite motif containing 14
  zinc and ring finger 4

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.