YWHAZ, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta

YWHAZ, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta

• This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and sheep orthologs. The encoded protein interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity. Several transcript variants that differ in the 5' UTR but that encode the same protein have been identified for this gene. [provided by RefSeq, Oct 2008]

• Gene Synonyms (14-3-3 protein zeta/delta, 14-3-3 delta, 14-3-3 protein/cytosolic phospholipase A2, 14-3-3 zeta, epididymis luminal protein 4, epididymis secretory protein Li 3, epididymis secretory protein Li 93, phospholipase A2, protein kinase C inhibitor protein-1, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, delta polypeptide, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide, tyrosine 3/tryptophan 5 -monooxygenase activation protein, zeta polypeptide, 14-3-3-zeta, HEL-S-3, HEL-S-93, HEL4, KCIP-1, POPCHAS, YWHAD,)
• NCBI Gene ID: 7534
• Species: Homo sapiens (Human)
• UNIPROT ID#>>D0PNI1
  UNIPROT ID#>>P63104
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta interacts with:

• AAR2 splicing factor
  actin related protein 2/3 complex, subunit 4
  ADAM metallopeptidase domain 22
  adaptor related protein complex 3 subunit beta 1
  adaptor-related protein complex 2, alpha 2 subunit
  adaptor-related protein complex 3, sigma 1 subunit
  ADP-ribosylation factor 4
  ADP-ribosylation factor 5
  ajuba LIM protein
  A-kinase anchoring protein 13
  AKT1 substrate 1
  Aly/REF export factor
  ankyrin repeat domain 55
  anterior gradient 2, protein disulphide isomerase family member
  apoptosis inhibitor 5
  argonaute RISC catalytic component 2
  aspartate-beta-hydroxylase
  aspartyl-tRNA synthetase
  ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit
  ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1
  ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1
  ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit
  autophagy related 16 like 1
  autophagy related 9A
  B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB
  BAG cochaperone 3
  BAR/IMD domain containing adaptor protein 2
  B-box and SPRY domain containing
  BCAR1 scaffold protein, Cas family member
  beta-1,4-galactosyltransferase 7
  beta-transducin repeat containing E3 ubiquitin protein ligase
  BRCA1 associated protein 1
  bromodomain containing 1
  bromodomain containing 4
  caldesmon 1
  capping protein (actin filament) muscle Z-line, beta
  caveolae associated 1
  caveolin 1, caveolae protein
  cell cycle associated protein 1
  cell division cycle 73
  cell division cycle associated 7
  centromere protein E
  centromere protein J
  centrosomal AT-AC splicing factor
  centrosomal protein 126
  centrosomal protein 131
  chaperonin containing Tcp1, subunit 4 (delta)
  chloride intracellular channel 4
  chromatin assembly factor 1 subunit A
  chromobox 4
  cingulin
  cingulin like 1
  cleavage and polyadenylation specific factor 6
  coenzyme Q2, polyprenyltransferase
  coiled-coil domain containing 125
  collagen, type I, alpha 1
  collagen, type III, alpha 1
  COP1 E3 ubiquitin ligase
  COP9 signalosome subunit 5
  COP9 signalosome subunit 7B
  COPI coat complex subunit epsilon
  CREB regulated transcription coactivator 2
  cullin 1
  cullin 2
  cullin 3
  cullin 7
  cullin associated and neddylation disassociated 1
  CWC27 spliceosome associated cyclophilin
  cytoplasmic FMR1 interacting protein 1
  cytoplasmic FMR1 interacting protein 2
  cytoskeleton-associated protein 4
  DDB1 and CUL4 associated factor 7
  DEAD (Asp-Glu-Ala-Asp) box polypeptide 6
  DEAD box helicase 1
  DEAD box helicase 3, X-linked
  dedicator of cytokinesis 7
  DEK proto-oncogene (DNA binding)
  denticleless E3 ubiquitin protein ligase homolog
  diablo IAP-binding mitochondrial protein
  DISC1 scaffold protein
  DNA damage inducible transcript 4
  DnaJ heat shock protein family (Hsp40) member B4
  DnaJ heat shock protein family (Hsp40) member C17
  dolichyl-di-phosphooligosaccharide-protein glycotransferase
  dual specificity phosphatase 16
  dynamin 1 like
  egl-9 family hypoxia inducible factor 3
  elongation factor Tu GTP binding domain containing 2
  endoplasmic reticulum protein 44
  enhancer of mRNA decapping 3
  epiplakin 1
  ERBB receptor feedback inhibitor 1
  erythrocyte membrane protein band 4.1 like 3
  eukaryotic translation initiation factor 2, subunit 1 alpha
  eukaryotic translation initiation factor 2, subunit 3, structural gene X-linked
  eukaryotic translation initiation factor 3 subunit A
  eukaryotic translation initiation factor 3, subunit L
  Ewing sarcoma breakpoint region 1
  exonuclease 1
  family with sequence similarity 120, member A
  family with sequence similarity 13 member B
  family with sequence similarity 163 member A
  family with sequence similarity 189 member A2
  family with sequence similarity 53 member C
  family with sequence similarity 98, member A
  FANCD2 and FANCI associated nuclease 1
  Fas associated factor 1
  F-box and WD repeat domain containing 11
  F-box protein 6
  fermitin family member 2
  fibronectin 1
  filamin, alpha
  FMRP translational regulator 1
  formin homology 2 domain containing 1
  fragile X mental retardation, autosomal homolog 2
  FSHD region gene 1
  fused in sarcoma
  G protein signaling modulator 3
  GABA type A receptor associated protein like 2
  GINS complex subunit 4
  golgi brefeldin A resistant guanine nucleotide exchange factor 1
  GTPase activating protein (SH3 domain) binding protein 1
  H1.2 linker histone, cluster member
  H3 clustered histone 1
  H4 clustered histone 1
  heat shock protein 1 (chaperonin)
  heat shock protein 8
  heat shock protein 90 alpha (cytosolic), class B member 1
  HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
  heparan sulfate 6-O-sulfotransferase 2
  heterogeneous nuclear ribonucleoprotein A1
  heterogeneous nuclear ribonucleoprotein A2/B1
  heterogeneous nuclear ribonucleoprotein F
  heterogeneous nuclear ribonucleoprotein H1
  heterogeneous nuclear ribonucleoprotein K
  heterogeneous nuclear ribonucleoprotein M
  HEXIM P-TEFb complex subunit 1
  high density lipoprotein (HDL) binding protein
  histone deacetylase 4
  histone deacetylase 5
  histone deacetylase 6
  histone deacetylase 7
  histone deacetylase 9
  insulin receptor substrate 2
  insulin receptor substrate 4
  insulin-like growth factor 2 mRNA binding protein 1
  integrin beta 3
  integrin beta 5
  interferon activated gene 202B
  isochorismatase domain containing 1
  kelch like family member 7
  KIAA0232
  KIAA0930
  kinase suppressor of ras 1
  kinase suppressor of ras 1
  kinesin family member 1C
  kinesin family member 23
  kinesin light chain 2
  kinesin light chain 4
  KN motif and ankyrin repeat domains 1
  Kruppel like factor 11
  La ribonucleoprotein 1, translational regulator
  large tumor suppressor kinase 2
  lebercilin LCA5
  lectin, galactose binding, soluble 9
  leucine rich repeat kinase 2
  ligand of numb-protein X 1
  lipoprotein lipase
  lysine acetyltransferase 8
  lysyl oxidase
  mannosyl-oligosaccharide glucosidase
  MAP kinase activating death domain
  MAPK activated protein kinase 2
  mediator of DNA damage checkpoint 1
  methylphosphate capping enzyme
  mex-3 RNA binding family member B
  microtubule affinity regulating kinase 4
  microtubule associated protein RP/EB family member 1
  microtubule associated serine/threonine kinase 1
  misshapen like kinase 1
  mitochondrial carrier 2
  mitogen-activated protein kinase 13
  mitogen-activated protein kinase kinase kinase 2
  mitogen-activated protein kinase kinase kinase 20
  MLX interacting protein-like
  moesin
  M-phase phosphoprotein 9
  MSL complex subunit 2
  MYC binding protein 2
  myosin, heavy polypeptide 10, non-muscle
  myosin, heavy polypeptide 11, smooth muscle
  myosin, heavy polypeptide 9, non-muscle
  myotubularin related protein 4
  NAD kinase
  NCK associated protein 1
  NEDD4 like E3 ubiquitin protein ligase
  neurobeachin like 2
  NKD inhibitor of WNT signaling pathway 2
  non-POU-domain-containing, octamer binding protein
  non-SMC condensin II complex subunit D3
  NSL1 component of MIS12 kinetochore complex
  nuclear receptor corepressor 1
  nuclear RNA export factor 1
  nucleolar and coiled-body phosphoprotein 1
  nucleophosmin 1
  Obg like ATPase 1
  obscurin like cytoskeletal adaptor 1
  optineurin
  p21 (RAC1) activated kinase 4
  p21 (RAC1) activated kinase 5
  p21 (RAC1) activated kinase 6
  par-3 family cell polarity regulator
  par-6 family cell polarity regulator alpha
  par-6 family cell polarity regulator beta
  Parkinsonism associated deglycase
  PDGFA associated protein 1
  peptidylprolyl isomerase E
  PHD finger protein 3
  PIH1 domain containing 1
  pleckstrin homology and RhoGEF domain containing G5
  pleckstrin homology domain containing A4
  plectin
  PNMA family member 1
  PNMA family member 2
  poly(A) binding protein cytoplasmic 4
  poly(rC) binding protein 1
  poly(rC) binding protein 2
  polycomb group ring finger 5
  potassium two pore domain channel subfamily K member 15
  potassium two pore domain channel subfamily K member 9
  PPFIA binding protein 1
  pre B cell leukemia transcription factor interacting protein 1
  pre-mRNA processing factor 18
  pre-mRNA processing factor 8
  prohibitin 2
  proline rich 14 like
  proline-rich coiled-coil 2C
  proteasome 26S subunit, non-ATPase 14
  protein arginine methyltransferase 5
  protein inhibitor of activated STAT 1
  protein phosphatase 1 catalytic subunit gamma
  protein phosphatase 1 regulatory inhibitor subunit 14A
  protein phosphatase, Mg2+/Mn2+ dependent 1H
  protein tyrosine phosphatase domain containing 1
  PTEN induced kinase 1
  pyruvate kinase, muscle
  RAB11 family interacting protein 1
  RAB11 family interacting protein 2
  Ral GEF with PH domain and SH3 binding motif 2
  RAP1 GTPase activating protein 2
  Ras and Rab interactor 1
  Ras association domain family member 2
  RAS protein activator like 3
  receptor accessory protein 1
  receptor interacting serine/threonine kinase 4
  RecQ like helicase 4
  regulation of nuclear pre-mRNA domain containing 1A
  regulator of microtubule dynamics 3
  regulatory associated protein of MTOR complex 1
  retinoic acid induced 14
  RHO family interacting cell polarization regulator 2
  Rho/Rac guanine nucleotide exchange factor 2
  ribophorin II
  ribosomal protein L10A
  ribosomal protein L19
  ribosomal protein L24
  ribosomal protein L26
  ribosomal protein L27
  ribosomal protein L3
  ribosomal protein L4
  ribosomal protein L6
  ribosomal protein L7
  ribosomal protein S15
  ribosomal protein S16
  ribosomal protein S23
  ribosomal protein S27A
  ribosomal protein S4, X-linked
  ribosomal protein S6 kinase A5
  ribosomal protein S8
  ribosomal protein, large, P0
  ring-box 1
  RNA binding motif protein 26
  RNA binding motif protein 27
  RNA transcription, translation and transport factor
  RRAD and GEM like GTPase 1
  salt inducible kinase 1
  salt inducible kinase 2
  salvador family WW domain containing protein 1
  SAM domain, SH3 domain and nuclear localization signals 1
  Sec61 beta subunit
  SEC61 translocon subunit alpha 1
  sequestosome 1
  serine (or cysteine) peptidase inhibitor, clade E, member 2
  serine and arginine rich splicing factor 8
  serine/threonine kinase 25
  serine/threonine kinase 38
  SIK family kinase 3
  SLC9A3 regulator 1
  slingshot protein phosphatase 1
  slingshot protein phosphatase 2
  slingshot protein phosphatase 3
  small nuclear ribonucleoprotein B
  small nuclear ribonucleoprotein D3
  small nuclear ribonucleoprotein U5 subunit 40
  smoothelin like 2
  solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4
  solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 5
  solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 3
  sorbin and SH3 domain containing 2
  sorting nexin 24
  spermatogenesis associated 13
  spire type actin nucleation factor 2
  splicing factor 3b subunit 1
  splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated)
  SPRY domain containing 3
  SSX family member 2 interacting protein
  STE20 like kinase
  sterile alpha motif domain containing 4A
  sterile alpha motif domain containing 4B
  stromal cell derived factor 4
  structural maintenance of chromosomes 1A
  SUMO interacting motifs containing 1
  synaptopodin
  synaptopodin 2
  synaptotagmin binding, cytoplasmic RNA interacting protein
  TAR DNA binding protein
  TATA-box binding protein associated factor 15
  TBC1 domain family member 4
  TBC1 domain family member 7
  testis expressed 33
  tet methylcytosine dioxygenase 2
  TGF-beta activated kinase 1 (MAP3K7) binding protein 2
  thymocyte expressed, positive selection associated 1
  thymopoietin
  tight junction protein 2
  tousled like kinase 2
  transcription factor EB
  transglutaminase 2, C polypeptide
  translocase of inner mitochondrial membrane 13
  transmembrane protein 214
  transmembrane protein 33
  tripartite motif containing 25
  tripartite motif containing 32
  tripartite motif containing 59
  tubulin alpha 1a
  tubulin beta class I
  tubulin, beta 2B class IIB
  tubulin, beta 6 class V
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
  tyrosine kinase non receptor 1
  U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 2
  U2 small nuclear RNA auxiliary factor 2
  ubiquitin conjugating enzyme E2 L6
  ubiquitin conjugating enzyme E2 M
  ubiquitin C-terminal hydrolase L5
  ubiquitin specific peptidase 8
  ubiquitin specific peptidase 8
  UDP-glucose dehydrogenase
  UHRF1 binding protein 1 like
  unk zinc finger
  vir like m6A methyltransferase associated
  WD repeat domain 62
  WD repeat domain 76
  WNK lysine deficient protein kinase 1
  WNK lysine deficient protein kinase 2
  WW domain containing E3 ubiquitin protein ligase 2
  WW domain containing oxidoreductase
  WW domain containing transcription regulator 1
  WW domain containing transcription regulator 1
  Y box protein 1
  Yes1 associated transcriptional regulator
  yes-associated protein 1
  YY1 associated factor 2
  zinc finger FYVE-type containing 19
  zinc finger protein 397
  zinc finger protein 839
  zinc fingers and homeoboxes 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.