DNAJB4, DnaJ heat shock protein family (Hsp40) member B4

DNAJB4, DnaJ heat shock protein family (Hsp40) member B4

• The protein encoded by this gene is a molecular chaperone, tumor suppressor, and member of the heat shock protein-40 family. The encoded protein binds the cell adhesion protein E-cadherin and targets it to the plasma membrane. This protein also binds incorrectly folded E-cadherin and targets it for endoplasmic reticulum-associated degradation. This gene is a strong tumor suppressor for colorectal carcinoma, and downregulation of it may serve as a good biomarker for predicting patient outcomes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

• Gene Synonyms (dnaJ homolog subfamily B member 4, DnaJ (Hsp40) homolog, subfamily B, member 4, DnaJ-like heat shock protein 40, HSP40 homolog, heat shock 40 kDa protein 1 homolog, heat shock protein 40 homolog, human liver DnaJ-like protein, DNAJW, DjB4, HLJ1,)
• NCBI Gene ID: 11080
• Species: Homo sapiens (Human)
• UNIPROT ID#>>B4DNN2
  UNIPROT ID#>>Q9UDY4
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

DnaJ heat shock protein family (Hsp40) member B4 interacts with:

• abhydrolase domain containing 15
  angiopoietin like 4
  ankyrin repeat and SOCS box containing 4
  apolipoprotein B mRNA editing enzyme catalytic subunit 3D
  BCL2-associated athanogene 2
  chromosome 3 open reading frame 38
  DnaJ heat shock protein family (Hsp40) member B5
  Ecm29 proteasome adaptor and scaffold
  F-box and WD repeat domain containing 11
  GrpE like 1, mitochondrial
  heat shock 105kDa/110kDa protein 1
  kinase suppressor of ras 1
  MANSC domain containing 1
  methyltransferase like 3
  myosin, heavy polypeptide 3, skeletal muscle, embryonic
  paraspeckle component 1
  pellino E3 ubiquitin protein ligase family member 3
  pleckstrin homology domain containing A4
  RNA polymerase I and III subunit D
  SHANK associated RH domain interactor
  solute carrier family 8 (sodium/calcium exchanger), member 1
  synemin
  TATA-box binding protein like 2
  TBC1 domain family member 22A
  transducin beta like 1 Y-linked
  trimethylguanosine synthase 1
  tubulin tyrosine ligase like 1
  tubulin tyrosine ligase like 12
  tubulin tyrosine ligase-like family, member 12
  WD repeat containing, antisense to TP73
  zinc finger and BTB domain containing 38

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.