IRS4, insulin receptor substrate 4

IRS4, insulin receptor substrate 4

• IRS4 encodes the insulin receptor substrate 4, a cytoplasmic protein that contains many potential tyrosine and serine/threonine phosphorylation sites. Tyrosine-phosphorylated IRS4 protein has been shown to associate with cytoplasmic signalling molecules that contain SH2 domains. The IRS4 protein is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation.. [provided by RefSeq, Jul 2008]

• Gene Synonyms (insulin receptor substrate 4, 160 kDa phosphotyrosine protein, phosphoprotein of 160 kDa, pp160, CHNG9, IRS-4, PY160,)
• NCBI Gene ID: 8471
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O14654
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

insulin receptor substrate 4 interacts with:

• agrin
  A-kinase anchoring protein 8 like
  alanyl-tRNA synthetase domain containing 1
  ankyrin repeat and SOCS box-containing 4
  anterior gradient 2, protein disulphide isomerase family member
  aurora kinase B
  autophagy and beclin 1 regulator 1
  bromodomain containing 7
  calcyclin binding protein
  caseinolytic mitochondrial matrix peptidase chaperone subunit B
  centrosomal protein 250
  centrosomal protein 57
  centrosomal protein 76
  clusterin associated protein 1
  coiled-coil domain containing 8
  COP9 signalosome subunit 5
  derlin 1
  DnaJ heat shock protein family (Hsp40) member A2
  DnaJ heat shock protein family (Hsp40) member A3
  dual specificity phosphatase 16
  dynein axonemal heavy chain 17
  egl-9 family hypoxia inducible factor 3
  F-box protein 7
  G protein-coupled receptor associated sorting protein 2
  glutamate rich WD repeat containing 1
  golgi brefeldin A resistant guanine nucleotide exchange factor 1
  HAUS augmin like complex subunit 2
  histone deacetylase 5
  insulin receptor substrate 4
  integrin alpha FG-GAP repeat containing 1
  La ribonucleoprotein 7, transcriptional regulator
  leptin receptor
  leucine rich repeat containing G protein-coupled receptor 4
  MAGE family member D1
  MAGE family member D2
  MAGE family member L2
  mindbomb E3 ubiquitin protein ligase 1
  myotubularin related protein 11
  NEDD1 gamma-tubulin ring complex targeting factor
  nephrocystin 4
  nischarin
  OTU deubiquitinase 3
  OTU deubiquitinase, ubiquitin aldehyde binding 1
  PH domain and leucine rich repeat protein phosphatase 1
  phosphoinositide-3-kinase regulatory subunit 3
  pleckstrin homology domain containing A4
  poly(A) specific ribonuclease subunit PAN2
  prolyl 4-hydroxylase subunit alpha 2
  prostaglandin E synthase 3
  protein tyrosine phosphatase non-receptor type 18
  PTEN induced kinase 1
  receptor interacting serine/threonine kinase 4
  RecQ like helicase 4
  required for meiotic nuclear division 5 homolog A
  ring finger and CCCH-type domains 1
  ring finger and CCCH-type domains 2
  ring finger protein 126
  ring finger protein 41
  salvador family WW domain containing protein 1
  sirtuin 7
  slingshot protein phosphatase 1
  solute carrier family 15 member 3
  STIP1 homology and U-box containing protein 1
  suppressor of cytokine signaling 2
  suppressor of cytokine signaling 6
  suppressor of cytokine signaling 7
  TBL1X receptor 1
  TNFAIP3 interacting protein 2
  trans-golgi network protein 2
  transmembrane protein 17
  transmembrane protein 216
  transmembrane protein 41B
  tubulin beta 4A class IVa
  tubulin beta 6 class V
  tubulin gamma complex associated protein 3
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
  ubiquitin specific peptidase 14
  ubiquitin specific peptidase 18
  UBX domain protein 6
  unc-93 homolog B1, TLR signaling regulator
  WD repeat domain 6
  Yes1 associated transcriptional regulator
  zinc finger protein 598, E3 ubiquitin ligase
  zinc finger protein 746

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.