PHLPP1, PH domain and leucine rich repeat protein phosphatase 1

PHLPP1, PH domain and leucine rich repeat protein phosphatase 1

• This gene encodes a member of the serine/threonine phosphatase family. The encoded protein promotes apoptosis by dephosphorylating and inactivating the serine/threonine kinase Akt, and functions as a tumor suppressor in multiple types of cancer. Increased expression of this gene may also play a role in obesity and type 2 diabetes by interfering with Akt-mediated insulin signaling. [provided by RefSeq, Dec 2011]

• Gene Synonyms (PHLPP, PLEKHE1, PPM3A, SCOP, PH domain leucine-rich repeat-containing protein phosphatase 1, PH domain-containing family E member 1, SCN circadian oscillatory protein, pleckstrin homology domain containing, family E (with leucine rich repeats) member 1, protein phosphatase, Mg2+/Mn2+ dependent 3A, suprachiasmatic nucleus circadian oscillatory protein,)
• NCBI Gene ID: 23239
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O60346
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

PH domain and leucine rich repeat protein phosphatase 1 interacts with:

• ATP/GTP binding protein 1
  BUD23 rRNA methyltransferase and ribosome maturation factor
  cytochrome c oxidase assembly factor 1 homolog
  FA complementation group I
  hepatitis A virus cellular receptor 2
  minichromosome maintenance complex binding protein
  NudC domain containing 3
  protein phosphatase 2, regulatory subunit B'', alpha
  RNA binding motif protein 15
  RNA polymerase II associated protein 3
  scribble planar cell polarity protein
  sorting nexin 27
  sorting nexin 6
  TATA-box binding protein associated factor 15
  TBC1 domain family member 7
  ubiquitin specific peptidase 12
  ubiquitin specific peptidase 46
  vir like m6A methyltransferase associated
  WD repeat domain 20
  WD repeat domain 48

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.