PTGES3, prostaglandin E synthase 3

PTGES3, prostaglandin E synthase 3

• This gene encodes an enzyme that converts prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). This protein functions as a co-chaperone with heat shock protein 90 (HSP90), localizing to response elements in DNA and disrupting transcriptional activation complexes. Alternative splicing results in multiple transcript variants. There are multiple pseudogenes of this gene on several different chromosomes. [provided by RefSeq, Feb 2016]

• Gene Synonyms (P23, TEBP, cPGES, prostaglandin E synthase 3, Hsp90 co-chaperone, cytosolic prostaglandin E synthase, cytosolic prostaglandin E2 synthase, progesterone receptor complex p23, prostaglandin E synthase 3 (cytosolic), telomerase-binding protein p23, unactive progesterone receptor, 23 kD,)
• NCBI Gene ID: 10728
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A087WYT3
  UNIPROT ID#>>A0A024RB32
  UNIPROT ID#>>B3KUY2
  UNIPROT ID#>>Q15185
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

prostaglandin E synthase 3 interacts with:

• 5'-nucleotidase, cytosolic II
  AAR2 splicing factor
  adenosylhomocysteinase like 1
  ankyrin repeat and MYND domain containing 2
  argonaute RISC component 4
  CD2 associated protein
  cell division cycle 37, HSP90 cochaperone
  centrosomal protein 290
  clusterin associated protein 1
  COPI coat complex subunit gamma 1
  COPI coat complex subunit gamma 2
  DEAH-box helicase 36
  DNA methyltransferase 3A
  dual specificity phosphatase 16
  egl-9 family hypoxia inducible factor 1
  FERM domain containing 5
  FKBP prolyl isomerase 8
  folliculin
  folliculin interacting protein 1
  folliculin interacting protein 2
  limb development membrane protein 1 like
  microtubule associated protein RP/EB family member 3
  nascent polypeptide associated complex subunit alpha 2
  NudC domain containing 2
  phosphoethanolamine/phosphocholine phosphatase 1
  PIH1 domain containing 1
  pleckstrin homology domain containing A4
  prostaglandin E synthase 3
  protein kinase C and casein kinase substrate in neurons 2
  receptor interacting serine/threonine kinase 4
  regulatory associated protein of MTOR complex 1
  SSU72 homolog, RNA polymerase II CTD phosphatase
  stress induced phosphoprotein 1
  TNFAIP3 interacting protein 2
  translocase of inner mitochondrial membrane 9
  ubiquitin related modifier 1
  unk zinc finger
  vesicle associated membrane protein 5
  vir like m6A methyltransferase associated
  WD repeat containing antisense to TP53

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.