UBE2L6, ubiquitin conjugating enzyme E2 L6

UBE2L6, ubiquitin conjugating enzyme E2 L6

• The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is highly similar in primary structure to the enzyme encoded by the UBE2L3 gene. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2011]

• Gene Synonyms (ubiquitin/ISG15-conjugating enzyme E2 L6, E2 ubiquitin-conjugating enzyme L6, retinoic acid induced gene B protein, ubiquitin carrier protein L6, ubiquitin conjugating enzyme E2L 6, ubiquitin-protein ligase L6, RIG-B, UBCH8,)
• NCBI Gene ID: 9246
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O14933
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

ubiquitin conjugating enzyme E2 L6 interacts with:

• actin related protein 1A
  ariadne RBR E3 ubiquitin protein ligase 1
  ariadne RBR E3 ubiquitin protein ligase 2
  ariadne RBR E3 ubiquitin protein ligase 2
  ATP binding cassette subfamily F member 2
  BAG cochaperone 2
  Cbl proto-oncogene C
  decapping mRNA 1A
  deltex E3 ubiquitin ligase 3
  DnaJ heat shock protein family (Hsp40) member A2
  dynactin subunit 2
  dynactin subunit 3
  HECT and RLD domain containing E3 ubiquitin protein ligase 5
  HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
  HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
  inner membrane mitochondrial protein
  ISG15 ubiquitin like modifier
  itchy E3 ubiquitin protein ligase
  LON peptidase N-terminal domain and ring finger 1
  mitochondrial E3 ubiquitin protein ligase 1
  NEDD4 like E3 ubiquitin protein ligase
  phosphoglycerate dehydrogenase
  pleckstrin homology domain containing A4
  poly(A) binding protein cytoplasmic 1
  praja ring finger ubiquitin ligase 2
  RANBP2-type and C3HC4-type zinc finger containing 1
  RanBP-type and C3HC4-type zinc finger containing 1
  receptor for activated C kinase 1
  ring finger protein 122
  ring finger protein 125
  ring finger protein 144A
  ring finger protein 144B
  ring finger protein 150
  ring finger protein 19A, RBR E3 ubiquitin protein ligase
  ring finger protein 19B
  ring finger protein 216
  ring finger protein 25
  ring finger protein 40
  ring-box 1
  RuvB like AAA ATPase 2
  septin 9
  spen family transcriptional repressor
  synaptotagmin binding cytoplasmic RNA interacting protein
  TAR DNA binding protein
  thyroid hormone receptor interactor 12
  TNF receptor associated factor 7
  TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase
  tripartite motif containing 62
  tripartite motif containing 8
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
  UBA domain containing 2
  ubiquitin conjugating enzyme E2 L6
  ubiquitin like modifier activating enzyme 6
  WW domain containing E3 ubiquitin protein ligase 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.