FAN1, FANCD2 and FANCI associated nuclease 1

FAN1, FANCD2 and FANCI associated nuclease 1

• This gene plays a role in DNA interstrand cross-link repair and encodes a protein with 5' flap endonuclease and 5'-3' exonuclease activity. Mutations in this gene cause karyomegalic interstitial nephritis. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Feb 2016]

• Gene Synonyms (KIAA1018, KMIN, MTMR15, hFAN1, fanconi-associated nuclease 1, FANCD2/FANCI-associated nuclease 1, coiled-coil domain-containing protein MTMR15, fanconi anemia associated nuclease 1, myotubularin-related protein 15,)
• NCBI Gene ID: 22909
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9Y2M0
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

FANCD2 and FANCI associated nuclease 1 interacts with:

• ankyrin repeat and LEM domain containing 2
  CD99 molecule like 2
  chromosome 1 open reading frame 52
  DExH-box helicase 57
  FA complementation group I
  FANCD2 and FANCI associated nuclease 1
  filamin binding LIM protein 1
  GADD45G interacting protein 1
  H3.5 histone
  HSPA (Hsp70) binding protein 1
  MIER1 transcriptional regulator
  mutL homolog 3
  NOP16 nucleolar protein
  nuclear receptor coactivator 5
  nudix hydrolase 16
  OTU deubiquitinase 4
  pleckstrin homology domain containing A8
  ribosomal protein S19 binding protein 1
  RNA binding motif protein 34
  trinucleotide repeat containing adaptor 6B
  WD repeat domain 75
  zinc finger protein 703

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.