IRS2, insulin receptor substrate 2

IRS2, insulin receptor substrate 2

• This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. The product of this gene is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment. [provided by RefSeq, Jul 2008]

• Gene Synonyms (insulin receptor substrate 2, IRS-2,)
• NCBI Gene ID: 8660
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9Y4H2
  UNIPROT ID#>>Q9P084
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

insulin receptor substrate 2 interacts with:

• COP9 signalosome subunit 2
  egl-9 family hypoxia inducible factor 3
  elongation factor Tu GTP binding domain containing 2
  epsin 1
  F-box and WD repeat domain containing 11
  metadherin
  mitochondrial ribosomal protein L1
  myotubularin related protein 4
  neuropilin and tolloid like 2
  nischarin
  regulatory associated protein of MTOR complex 1
  SH2B adaptor protein 1
  sirtuin 1
  sirtuin 1
  suppressor of cytokine signaling 3
  suppressor of cytokine signaling 6
  suppressor of cytokine signaling 7
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
  ubiquitin specific peptidase 15
  vir like m6A methyltransferase associated

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.