FBXL7, F-box and leucine rich repeat protein 7

FBXL7, F-box and leucine rich repeat protein 7

• This gene encodes a member of the F-box protein family which is characterized by a 42-48 amino acid motif, the F-box, which binds to the S-phase kinase-associated protein 1 (Skp1) protein. The F-box proteins constitute one of the four subunits of E3 ubiquitin protein ligases called SCFs (SKP1-Cul1-F-box), which play a role in phosphorylation-dependent ubiquitination of proteins. The F-box proteins are divided into 3 subfamilies based on the other domain in the protein: F-box proteins that also have a WD-40 domain (Fbws subfamily), F-box proteins that also have leucine-rich repeats (Fbls subfamily) and F-box proteins that contain other motifs or lack known protein-interaction domains (Fbxs subfamily). The protein encoded by this gene belongs to the Fbls subfamily. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]

• Gene Synonyms (FBL6, FBL7, F-box/LRR-repeat protein 7, F-box protein Fbl7,)
• NCBI Gene ID: 23194
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9UJT9
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

F-box and leucine rich repeat protein 7 interacts with:

• F-box and leucine rich repeat protein 18
  ring finger protein 123
  WD repeat domain 48

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