UBE2B, ubiquitin conjugating enzyme E2 B

UBE2B, ubiquitin conjugating enzyme E2 B

• The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair. Its protein sequence is 100% identical to the mouse, rat, and rabbit homologs, which indicates that this enzyme is highly conserved in eukaryotic evolution. [provided by RefSeq, Jul 2008]

• Gene Synonyms (ubiquitin-conjugating enzyme E2 B, E2 protein, E2 ubiquitin-conjugating enzyme B, RAD6 homolog B, ubiquitin carrier protein B, ubiquitin conjugating enzyme E2B, ubiquitin-conjugating enzyme E2-17 kDa, ubiquitin-conjugating enzyme E2B (RAD6 homolog), ubiquitin-protein ligase B, E2-17kDa, HHR6B, HR6B, RAD6B, UBC2,)
• NCBI Gene ID: 7320
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P63146
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

ubiquitin conjugating enzyme E2 B interacts with:

• abhydrolase domain containing 10, depalmitoylase
  acyl-CoA thioesterase 9
  adenosylhomocysteinase like 1
  ATPase H+ transporting V1 subunit F
  chromobox 5
  complexin 1
  destrin, actin depolymerizing factor
  H2A clustered histone 20
  HERPUD family member 2
  mediator complex subunit 31
  nipsnap homolog 1
  nipsnap homolog 3A
  peroxiredoxin 5
  phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase
  potassium channel modulatory factor 1
  RAD18 E3 ubiquitin protein ligase
  ring finger and CCCH-type domains 1
  ring finger and CCCH-type domains 2
  ring finger protein 20
  ring finger protein 40
  Sec23 homolog A, COPII coat complex component
  SEC24 homolog A, COPII coat complex component
  seryl-tRNA synthetase 2, mitochondrial
  SMC5-SMC6 complex localization factor 1
  sulfiredoxin 1
  tripartite motif containing 14
  tripartite motif containing 45
  tubulin tyrosine ligase like 12
  ubiquilin 1
  ubiquilin 4
  ubiquitin conjugating enzyme E2 B
  ubiquitin conjugating enzyme E2 C
  ubiquitin conjugating enzyme E2 D1
  ubiquitin conjugating enzyme E2 L3
  ubiquitin conjugating enzyme E2 V1
  ubiquitin conjugating enzyme E2 V2
  ubiquitin like modifier activating enzyme 2
  ubiquitin protein ligase E3 component n-recognin 1
  ubiquitin protein ligase E3 component n-recognin 2
  ubiquitin protein ligase E3 component n-recognin 3
  ubiquitin protein ligase E3 component n-recognin 4
  ubiquitin protein ligase E3 component n-recognin 5
  ubiquitin specific peptidase 9 X-linked
  UBX domain protein 7
  unc-119 lipid binding chaperone
  unk zinc finger
  WW domain containing adaptor with coiled-coil
  zinc finger FYVE-type containing 19
  zinc finger MYM-type containing 2
  zinc finger RANBP2-type containing 2
  zinc ribbon domain containing 2
  zyxin

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.