PSMC2, proteasome 26S subunit, ATPase 2

PSMC2, proteasome 26S subunit, ATPase 2

• The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit has been shown to interact with several of the basal transcription factors so, in addition to participation in proteasome functions, this subunit may participate in the regulation of transcription. This subunit may also compete with PSMC3 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Mar 2011]

• Gene Synonyms (26S proteasome regulatory subunit 7, 26S protease regulatory subunit 7, 26S proteasome AAA-ATPase subunit RPT1, mammalian suppressor of sgv-1 of yeast, protease 26S subunit 7, proteasome (prosome, macropain) 26S subunit, ATPase, 2, putative protein product of Nbla10058, testis secretory sperm-binding protein Li 197a, MSS1, Nbla10058, S7,)
• NCBI Gene ID: 5701
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P35998
  UNIPROT ID#>>B7Z571
  UNIPROT ID#>>A0A140VK70
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

proteasome 26S subunit, ATPase 2 interacts with:

• AAR2 splicing factor
  adhesion regulating molecule 1
  aldehyde dehydrogenase 1 family member L1
  ASXL transcriptional regulator 1
  ataxin 7
  ATP binding cassette subfamily E member 1
  autophagy and beclin 1 regulator 1
  autophagy related 4C cysteine peptidase
  BAG cochaperone 3
  BRCA1 associated protein 1
  CAP-Gly domain containing linker protein 1
  CCR4-NOT transcription complex subunit 7
  cell division cycle 73
  centrosomal protein 55
  centrosomal protein 85
  chaperonin containing TCP1 subunit 2
  chaperonin containing TCP1 subunit 3
  chaperonin containing TCP1 subunit 4
  chaperonin containing TCP1 subunit 6B
  chaperonin containing TCP1 subunit 8
  coiled-coil domain containing 74B
  coiled-coil domain containing 92
  cullin 3
  derlin 1
  desumoylating isopeptidase 1
  DnaJ heat shock protein family (Hsp40) member A4
  dual specificity phosphatase 16
  dynactin subunit 2
  dynamin 1 like
  Ecm29 proteasome adaptor and scaffold
  egl-9 family hypoxia inducible factor 3
  exportin 1
  Fas associated factor 1
  F-box protein 6
  FKBP prolyl isomerase 8
  FtsJ RNA 2'-O-methyltransferase 3
  HECT and RLD domain containing E3 ubiquitin protein ligase 3
  HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
  HEXIM P-TEFb complex subunit 1
  hypoxia inducible factor 1 subunit alpha inhibitor
  importin 4
  insulin induced gene 2
  karyopherin subunit alpha 6
  kinase suppressor of ras 1
  L3MBTL histone methyl-lysine binding protein 1
  La ribonucleoprotein 7, transcriptional regulator
  limb development membrane protein 1 like
  methylphosphate capping enzyme
  midline 2
  mitochondrial carrier 1
  mitochondrial ribosomal protein S16
  multiple coagulation factor deficiency 2, ER cargo receptor complex subunit
  myotubularin related protein 1
  NDC80 kinetochore complex component
  neuralized E3 ubiquitin protein ligase 4
  NFS1 cysteine desulfurase
  ninein
  N-myc downstream regulated 1
  nuclear receptor subfamily 2 group C member 2
  nuclear RNA export factor 1
  patched 1
  pleckstrin homology domain containing A4
  PR/SET domain 16
  proteasomal ATPase associated factor 1
  proteasome (prosome, macropain) 26S subunit, non-ATPase, 6
  proteasome (prosome, macropain) subunit, beta type 4
  proteasome (prosome, macropain) subunit, beta type 5
  proteasome 20S subunit alpha 8
  proteasome 26S subunit, ATPase 2
  proteasome 26S subunit, ATPase 3
  proteasome 26S subunit, ATPase 4
  proteasome 26S subunit, ATPase 5
  proteasome 26S subunit, ATPase 6
  proteasome 26S subunit, non-ATPase 1
  proteasome 26S subunit, non-ATPase 10
  proteasome 26S subunit, non-ATPase 11
  proteasome 26S subunit, non-ATPase 12
  proteasome 26S subunit, non-ATPase 13
  proteasome 26S subunit, non-ATPase 14
  proteasome 26S subunit, non-ATPase 2
  proteasome 26S subunit, non-ATPase 3
  proteasome 26S subunit, non-ATPase 4
  proteasome 26S subunit, non-ATPase 5
  proteasome 26S subunit, non-ATPase 6
  proteasome 26S subunit, non-ATPase 7
  proteasome 26S subunit, non-ATPase 8
  proteasome 26S subunit, non-ATPase 9
  proteasome activator subunit 1
  proteasome activator subunit 2
  proteasome activator subunit 3
  proteasome maturation protein
  protein phosphatase, Mg2+/Mn2+ dependent 1D
  protein tyrosine phosphatase non-receptor type 2
  protocadherin 10
  RAB5C, member RAS oncogene family
  RAD21 cohesin complex component
  RAD23 homolog A, nucleotide excision repair protein
  RAD23 homolog B, nucleotide excision repair protein
  receptor interacting serine/threonine kinase 4
  RecQ like helicase 4
  RELA proto-oncogene, NF-kB subunit
  ribophorin I
  ribosomal protein L35
  ribosomal protein lateral stalk subunit P2
  ribosomal protein S21
  ribosomal protein S6 kinase B2
  ring finger protein 185
  ring finger protein 2
  RNA polymerase II subunit M
  Sec23 homolog A, COPII coat complex component
  SEM1 26S proteasome complex subunit
  sequestosome 1
  serine hydroxymethyltransferase 2
  sirtuin 7
  SKI like proto-oncogene
  small nuclear ribonucleoprotein U5 subunit 200
  small ubiquitin like modifier 4
  snail family transcriptional repressor 1
  SNW domain containing 1
  SprT-like N-terminal domain
  structural maintenance of chromosomes 1A
  structural maintenance of chromosomes 3
  succinate dehydrogenase complex flavoprotein subunit A
  succinate-CoA ligase ADP-forming subunit beta
  superoxide dismutase 1
  TATA-box binding protein
  TATA-box binding protein associated factor 2
  thioredoxin interacting protein
  thioredoxin like 1
  thymopoietin
  TNF receptor associated factor 6
  TNFAIP3 interacting protein 2
  transformed mouse 3T3 cell double minute 2
  transmembrane protein 41B
  tripartite motif containing 28
  tripartite motif containing 5
  tropomyosin 4
  tubulin beta class I
  ubiquilin 1
  ubiquilin 2
  ubiquilin 4
  ubiquitin C
  ubiquitin conjugating enzyme E2 C
  ubiquitin conjugating enzyme E2 M
  ubiquitin C-terminal hydrolase L5
  ubiquitin like domain containing CTD phosphatase 1
  ubiquitin protein ligase E3 component n-recognin 2
  ubiquitin protein ligase E3 component n-recognin 5
  ubiquitin protein ligase E3A
  ubiquitin specific peptidase 14
  ubiquitin specific peptidase 15
  ubiquitin specific peptidase 44
  ubiquitin-fold modifier conjugating enzyme 1
  unc-93 homolog B1, TLR signaling regulator
  VHL binding protein 1
  vir like m6A methyltransferase associated
  VPS26, retromer complex component A
  WW domain containing oxidoreductase
  Yes1 associated transcriptional regulator
  YY1 associated factor 2
  zinc finger CCHC-type containing 8
  zinc finger protein 598, E3 ubiquitin ligase

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.