TAF2, TATA-box binding protein associated factor 2

TAF2, TATA-box binding protein associated factor 2

• Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the larger subunits of TFIID that is stably associated with the TFIID complex. It contributes to interactions at and downstream of the transcription initiation site, interactions that help determine transcription complex response to activators. [provided by RefSeq, Jul 2008]

• Gene Synonyms (transcription initiation factor TFIID subunit 2, 150 kDa cofactor of initiator function, RNA polymerase II TBP-associated factor subunit B, TAF(II)150, TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa, TATA box binding protein (TBP)-associated factor, RNA polymerase II, B, 150kD, TBP-associated factor 150 kDa, cofactor of initiator function, 150kD subunit, transcription initiation factor TFIID 150 kDa subunit, CIF150, MRT40, TAF2B, TAFII150,)
• NCBI Gene ID: 6873
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A024R9E6
  UNIPROT ID#>>Q6P1X5
  UNIPROT ID#>>B3KMD8
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

TATA-box binding protein associated factor 2 interacts with:

• 2-oxoglutarate and iron dependent oxygenase domain containing 1
  adenylate kinase 9
  centromere protein M
  DNA polymerase delta 3, accessory subunit
  erythrocyte membrane protein band 4.1 like 3
  eukaryotic translation initiation factor 3 subunit H
  exportin 1
  factor interacting with PAPOLA and CPSF1
  family with sequence similarity 50 member A
  gem nuclear organelle associated protein 4
  growth factor independent 1B transcriptional repressor
  H3 clustered histone 1
  H3.4 histone
  HECT and RLD domain containing E3 ubiquitin protein ligase 2
  integrator complex subunit 5
  ISG15 ubiquitin like modifier
  kinesin family member 4
  leucyl-tRNA synthetase 1
  lysine demethylase 5B
  mediator complex subunit 26
  mitochondrial ribosomal protein L18
  mitochondrial ribosomal protein L27
  mitochondrial ribosomal protein S11
  mitochondrial ribosomal protein S5
  N-alpha-acetyltransferase 25, NatB auxiliary subunit
  ninein
  nuclear transport factor 2
  POC1 centriolar protein A
  poly(U) binding splicing factor 60
  polyamine modulated factor 1
  proteasome 26S subunit, non-ATPase 6
  RAD18 E3 ubiquitin protein ligase
  RAD50 interactor 1
  RNA binding protein with serine rich domain 1
  RNA guanylyltransferase and 5'-phosphatase
  RNA polymerase I subunit H
  SAMM50 sorting and assembly machinery component
  SEC22 homolog B, vesicle trafficking protein
  SEM1 26S proteasome complex subunit
  sirtuin 1
  TATA-box binding protein
  TATA-box binding protein associated factor 10
  TATA-box binding protein associated factor 11
  TATA-box binding protein associated factor 12
  TATA-box binding protein associated factor 13
  TATA-box binding protein associated factor 4
  TATA-box binding protein associated factor 5
  TATA-box binding protein associated factor 6
  TATA-box binding protein associated factor 7
  TATA-box binding protein associated factor 7 like
  TATA-box binding protein associated factor 8
  TATA-box binding protein associated factor 9
  telomeric repeat binding factor 1
  telomeric repeat binding factor 2
  TIMELESS interacting protein
  ubiquitin like modifier activating enzyme 2
  unconventional SNARE in the ER 1
  WD repeat domain 61
  WD repeat domain 7
  WD repeat domain 77
  YTH domain containing 1
  zinc finger HIT-type containing 6
  ZW10 interacting kinetochore protein

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.