TERF2, telomeric repeat binding factor 2

TERF2, telomeric repeat binding factor 2

• This gene encodes a telomere specific protein, TERF2, which is a component of the telomere nucleoprotein complex. This protein is present at telomeres in metaphase of the cell cycle, is a second negative regulator of telomere length and plays a key role in the protective activity of telomeres. While having similar telomere binding activity and domain organization, TERF2 differs from TERF1 in that its N terminus is basic rather than acidic. [provided by RefSeq, Jul 2008]

• Gene Synonyms (telomeric repeat-binding factor 2, TTAGGG repeat-binding factor 2, telomeric DNA-binding protein, telomeric repeat binding protein 2, TRBF2, TRF2,)
• NCBI Gene ID: 7014
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q15554
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

telomeric repeat binding factor 2 interacts with:

• 5'-nucleotidase domain containing 2
  ACD shelterin complex subunit and telomerase recruitment factor
  actin filament associated protein 1 like 2
  ADP ribosylation factor like GTPase 4C
  AKT interacting protein
  aminoadipate-semialdehyde synthase
  armadillo repeat containing 6
  aspartyl-tRNA synthetase 2, mitochondrial
  BAG cochaperone 3
  BAR/IMD domain containing adaptor protein 2 like 1
  BMP2 inducible kinase
  branched chain keto acid dehydrogenase kinase
  bromodomain containing 7
  BTG3 associated nuclear protein
  caseinolytic mitochondrial matrix peptidase chaperone subunit B
  caveolae associated protein 1
  CDKN2A interacting protein
  cell division cycle 37, HSP90 cochaperone
  chromodomain helicase DNA binding protein 7
  chromodomain helicase DNA binding protein 8
  chromosome 20 open reading frame 27
  chromosome alignment maintaining phosphoprotein 1
  CLK4 associating serine/arginine rich protein
  coactivator associated arginine methyltransferase 1
  coiled-coil domain containing 106
  coiled-coil domain containing 137
  cyclin dependent kinase 13
  cytoplasmic FMR1 interacting protein 1
  DEAD-box helicase 24
  DEAH-box helicase 33
  DEAH-box helicase 37
  DEAH-box helicase 40
  DExD-box helicase 21
  DExD-box helicase 39A
  DNA cross-link repair 1B
  DNA cross-link repair 1B
  DNA polymerase delta interacting protein 3
  DNA topoisomerase II alpha
  DNA topoisomerase III alpha
  DnaJ heat shock protein family (Hsp40) member A2
  DnaJ heat shock protein family (Hsp40) member B11
  dual specificity phosphatase 11
  enhancer of mRNA decapping 3
  eukaryotic elongation factor, selenocysteine-tRNA specific
  F-box protein 21
  fibroblast growth factor receptor like 1
  FMR1 autosomal homolog 2
  forkhead box J3
  G3BP stress granule assembly factor 2
  glucosidase II alpha subunit
  glycine N-methyltransferase
  G-patch domain containing 8
  H2A clustered histone 20
  H2A clustered histone 4
  H2B clustered histone 8
  H4 clustered histone 1
  HDGF like 2
  heat shock protein 90 beta family member 1
  heat shock protein family A (Hsp70) member 4 like
  heat shock protein family H (Hsp110) member 1
  HEXIM P-TEFb complex subunit 1
  HEXIM P-TEFb complex subunit 2
  high mobility group nucleosomal binding domain 3
  high mobility group nucleosomal binding domain 4
  insulin receptor substrate 4
  kinesin family member 13B
  La ribonucleoprotein 7, transcriptional regulator
  LanC like 2
  Ly1 antibody reactive
  mago homolog B, exon junction complex subunit
  mediator of DNA damage checkpoint 1
  meiosis regulator and mRNA stability factor 1
  methylcrotonoyl-CoA carboxylase 2
  microtubule actin crosslinking factor 1
  minichromosome maintenance complex component 3 associated protein
  mono-ADP ribosylhydrolase 2
  Mtr4 exosome RNA helicase
  MUS81 structure-specific endonuclease subunit
  myomesin 2
  neurite extension and migration factor
  nuclear apoptosis inducing factor 1
  nucleoredoxin like 1
  NUMB endocytic adaptor protein
  origin recognition complex subunit 3
  origin recognition complex subunit 6
  oxysterol binding protein like 11
  oxysterol binding protein like 9
  PAX3 and PAX7 binding protein 1
  peroxiredoxin 3
  peroxiredoxin 4
  phosphoinositide-3-kinase regulatory subunit 3
  phosphoribosyl pyrophosphate synthetase 1 like 1
  pitrilysin metallopeptidase 1
  pleckstrin homology domain containing A4
  poly(A) binding protein cytoplasmic 4
  potassium channel tetramerization domain containing 15
  pre-mRNA processing factor 40 homolog A
  protection of telomeres 1
  protein arginine methyltransferase 5
  protein inhibitor of activated STAT 1
  protein phosphatase 1, regulatory subunit 10
  pyrroline-5-carboxylate reductase 2
  RAD50 double strand break repair protein
  Ral GTPase activating protein catalytic subunit alpha 1
  RasGEF domain family member 1C
  regulation of nuclear pre-mRNA domain containing 1B
  replication initiator 1
  retrotransposon Gag like 6
  Rho GTPase activating protein 20
  ribonucleoprotein, PTB binding 1
  ring finger protein 113A
  ring finger protein 40
  RNA binding motif protein 15B
  RNA binding motif protein 33
  round spermatid basic protein 1 like
  SAFB like transcription modulator
  SAP30 binding protein
  SEC16 homolog A, endoplasmic reticulum export factor
  SEC24 homolog B, COPII coat complex component
  serine and arginine rich splicing factor 11
  serine/arginine repetitive matrix 2
  SLX4 structure-specific endonuclease subunit
  sorting nexin 22
  spectrin repeat containing nuclear envelope protein 1
  spectrin repeat containing nuclear envelope protein 2
  splicing factor 3b subunit 2
  splicing factor 3b subunit 4
  STIP1 homology and U-box containing protein 1
  stromal cell derived factor 2 like 1
  structural maintenance of chromosomes 3
  SUB1 regulator of transcription
  talin 1
  tankyrase
  TATA-box binding protein like 1
  TBC1 domain family member 15
  telomeric repeat binding factor 1
  telomeric repeat binding factor 2
  TERF1 interacting nuclear factor 2
  TERF2 interacting protein
  testis expressed 264, ER-phagy receptor
  thymosin beta 10
  thyroid hormone receptor associated protein 3
  torsin 1A interacting protein 1
  TOX high mobility group box family member 4
  transcription factor AP-4
  transcriptional adaptor 2B
  transient receptor potential cation channel subfamily C member 5
  tripartite motif containing 47
  tudor domain containing 6
  tuftelin interacting protein 11
  tumor protein p53 binding protein 1
  U2 small nuclear RNA auxiliary factor 2
  ubiquitin conjugating enzyme E2 I
  ubiquitin C-terminal hydrolase L1
  ubiquitin specific peptidase 15
  ubiquitin specific peptidase 9 X-linked
  UDP-glucose 6-dehydrogenase
  utrophin
  valosin containing protein
  vir like m6A methyltransferase associated
  WD repeat domain 4
  WD repeat domain 5
  WRN RecQ like helicase
  X antigen family member 1A
  X-ray repair cross complementing 5
  YY1 transcription factor
  zinc finger and BTB domain containing 10
  zinc finger CCCH-type and G-patch domain containing
  zinc finger CCCH-type containing 13
  zinc finger CCCH-type containing 18
  zinc finger CCCH-type containing, antiviral 1 like
  zinc finger protein 281
  zinc finger protein 703
  zinc finger with KRAB and SCAN domains 4

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.