ORC6, origin recognition complex subunit 6

ORC6, origin recognition complex subunit 6

• The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Gene silencing studies with small interfering RNA demonstrated that this protein plays an essential role in coordinating chromosome replication and segregation with cytokinesis. [provided by RefSeq, Oct 2010]

• Gene Synonyms (origin recognition complex subunit 6, ORC6L,)
• NCBI Gene ID: 23594
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A024R6R3
  UNIPROT ID#>>Q9Y5N6
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

origin recognition complex subunit 6 interacts with:

• actin related protein 10
  leucine rich repeats and WD repeat domain containing 1
  LIM homeobox 4
  origin recognition complex subunit 3
  paraspeckle component 1
  peptidylprolyl isomerase like 4

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.