AASS, aminoadipate-semialdehyde synthase

AASS, aminoadipate-semialdehyde synthase

• This gene encodes a bifunctional enzyme that catalyzes the first two steps in the mammalian lysine degradation pathway. The N-terminal and the C-terminal portions of this enzyme contain lysine-ketoglutarate reductase and saccharopine dehydrogenase activity, respectively, resulting in the conversion of lysine to alpha-aminoadipic semialdehyde. Mutations in this gene are associated with familial hyperlysinemia. [provided by RefSeq, Jul 2008]

• Gene Synonyms (alpha-aminoadipic semialdehyde synthase, mitochondrial, alpha-aminoadipate semialdehyde synthase, aminoadipic semialdehyde synthase, lysine-2-oxoglutarate reductase, lysine-ketoglutarate reductase /saccharopine dehydrogenase, LKR/SDH, LKRSDH, LORSDH,)
• NCBI Gene ID: 10157
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9UDR5
  UNIPROT ID#>>A4D0W4
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

aminoadipate-semialdehyde synthase interacts with:

• decapping mRNA 1A
  F-box and leucine rich repeat protein 13
  hook microtubule tethering protein 1
  hook microtubule tethering protein 3
  ninein
  pleckstrin homology domain containing A4
  staphylococcal nuclease and tudor domain containing 1
  tRNA methyltransferase 61B
  VPS37D subunit of ESCRT-I

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.