TDP2, tyrosyl-DNA phosphodiesterase 2

TDP2, tyrosyl-DNA phosphodiesterase 2

• This gene encodes a member of a superfamily of divalent cation-dependent phosphodiesterases. The encoded protein associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor associated factors (TRAFs), and inhibits nuclear factor-kappa-B activation. This protein has sequence and structural similarities with APE1 endonuclease, which is involved in both DNA repair and the activation of transcription factors. [provided by RefSeq, Jul 2008]

• Gene Synonyms (tyrosyl-DNA phosphodiesterase 2, 5'-Tyr-DNA phosphodiesterase, 5'-tyrosyl-DNA phosphodiesterase, ETS1-associated protein 2, ETS1-associated protein II, TRAF and TNF receptor-associated protein, VPg unlinkase, epididymis secretory sperm binding protein, tyr-DNA phosphodiesterase 2, tyrosyl-RNA phosphodiesterase, AD022, EAP2, EAPII, TTRAP, dJ30M3.3, hTDP2,)
• NCBI Gene ID: 51567
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O95551
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

tyrosyl-DNA phosphodiesterase 2 interacts with:

• antizyme inhibitor 1
  BTB domain containing 2
  chromosome 2 open reading frame 88
  golgi reassembly stacking protein 1
  junctional adhesion molecule 2
  LY6/PLAUR domain containing 4
  OTU deubiquitinase, ubiquitin aldehyde binding 1
  round spermatid basic protein 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.