RARA, retinoic acid receptor alpha

RARA, retinoic acid receptor alpha

• This gene represents a nuclear retinoic acid receptor. The encoded protein, retinoic acid receptor alpha, regulates transcription in a ligand-dependent manner. This gene has been implicated in regulation of development, differentiation, apoptosis, granulopoeisis, and transcription of clock genes. Translocations between this locus and several other loci have been associated with acute promyelocytic leukemia. Alternatively spliced transcript variants have been found for this locus.[provided by RefSeq, Sep 2010]

• Gene Synonyms (retinoic acid receptor alpha, RAR-alpha, nuclear receptor subfamily 1 group B member 1, nucleophosmin-retinoic acid receptor alpha fusion protein NPM-RAR long form, retinoic acid nuclear receptor alpha variant 1, retinoic acid nuclear receptor alpha variant 2, retinoic acid receptor, alpha polypeptide, NR1B1, RAR,)
• NCBI Gene ID: 5914
• Species: Homo sapiens (Human)
• UNIPROT ID#>>F1D8N9
  UNIPROT ID#>>P10276
  UNIPROT ID#>>A8K840
  UNIPROT ID#>>A8MUP8
  UNIPROT ID#>>Q6I9R7
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

retinoic acid receptor alpha interacts with:

• acidic nuclear phosphoprotein 32 family member A
  ajuba LIM protein
  ALX homeobox 1
  ATPase phospholipid transporting 8B2
  AT-rich interaction domain 1A
  AT-rich interaction domain 5A
  CCR4-NOT transcription complex subunit 1
  centrosomal protein 83
  chromobox 5
  clock circadian regulator
  COP9 signalosome subunit 2
  cyclin D1 binding protein 1
  desmoglein 4
  DNA topoisomerase II beta
  growth arrest and DNA damage inducible gamma
  growth arrest and DNA-damage-inducible 45 beta
  H2A clustered histone 1
  H2A clustered histone 21
  H2A clustered histone 6
  H2A.Z variant histone 2
  H2B clustered histone 4
  H3.4 histone
  HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1
  heterogeneous nuclear ribonucleoprotein A0
  histone deacetylase 3
  histone deacetylase 4
  HR lysine demethylase and nuclear receptor corepressor
  integrin subunit beta 1 binding protein 2
  iroquois homeobox 4
  KH RNA binding domain containing, signal transduction associated 1
  leucine rich repeat containing 15
  ligand dependent nuclear receptor interacting factor 1
  LIM domains containing 1
  lysine acetyltransferase 2B
  lysine demethylase 5A
  macroH2A.2 histone
  mediator complex subunit 25
  mediator complex subunit 6
  metastasis associated 1 family member 2
  methyl-CpG binding domain protein 3
  microspherule protein 1
  mitochondrial trans-2-enoyl-CoA reductase
  MMS19 homolog, cytosolic iron-sulfur assembly component
  MRT4 homolog, ribosome maturation factor
  NK2 homeobox 1
  nuclear receptor binding factor 2
  nuclear receptor binding SET domain protein 1
  nuclear receptor coactivator 1
  nuclear receptor coactivator 2
  nuclear receptor coactivator 3
  nuclear receptor coactivator 6
  nuclear receptor corepressor 1
  nuclear receptor corepressor 2
  nuclear receptor interacting protein 1
  nuclear receptor interacting protein 2
  nuclear receptor subfamily 0 group B member 2
  nuclear receptor subfamily 0, group B, member 2
  nuclear receptor subfamily 1 group H member 2
  nuclear receptor subfamily 1 group H member 3
  nuclear receptor subfamily 2 group C member 1
  nuclear receptor subfamily 2 group E member 3
  nuclear receptor subfamily 4, group A, member 1
  nuclear receptor-binding SET-domain protein 1
  paraspeckle component 1
  peroxiredoxin 6
  PHD finger protein 8
  plakophilin 3
  pleckstrin homology and FYVE domain containing 2
  PML-RARA regulated adaptor molecule 1
  PRAME nuclear receptor transcriptional regulator
  proline rich nuclear receptor coactivator 2
  replication factor C subunit 4
  retinoic acid receptor alpha
  retinoic acid receptor beta
  retinoic acid receptor gamma
  retinoid X receptor alpha
  retinoid X receptor beta
  retinoid X receptor gamma
  ribosomal L1 domain containing 1
  ribosomal protein S27a
  RNA binding motif protein 3
  RuvB like AAA ATPase 1
  S100 calcium binding protein A3
  selenium binding protein 1
  sequestosome 1
  serum response factor
  siah E3 ubiquitin protein ligase 1
  signal transducer and activator of transcription 5B
  Sin3A associated protein 130
  sirtuin 1
  SKI proto-oncogene
  small nuclear ribonucleoprotein U1 subunit 70
  small nuclear ribonucleoprotein U5 subunit 40
  SNW domain containing 1
  Sp1 transcription factor
  spen family transcriptional repressor
  Spi-1 proto-oncogene
  SRC proto-oncogene, non-receptor tyrosine kinase
  suppressor of variegation 3-9 homolog 1
  SUZ12 polycomb repressive complex 2 subunit
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
  TBL1X receptor 1
  tektin 4
  thymine DNA glycosylase
  thyroid hormone receptor interactor 4
  TNF receptor superfamily member 10b
  TNFAIP3 interacting protein 1
  transcriptional adaptor 3
  transmembrane protein 54
  tribbles pseudokinase 3
  tripartite motif containing 24
  tripartite motif containing 25
  tripartite motif containing 32
  ubiquilin 1
  ubiquitin protein ligase E3A
  ubiquitin specific peptidase 7
  WT1 interacting protein
  WW domain containing oxidoreductase
  zinc finger and BTB domain containing 16
  zinc finger protein 131

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.