SRC, SRC proto-oncogene, non-receptor tyrosine kinase

SRC, SRC proto-oncogene, non-receptor tyrosine kinase

• This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

• Gene Synonyms (proto-oncogene tyrosine-protein kinase Src, proto-oncogene c-Src, protooncogene SRC, Rous sarcoma, tyrosine kinase pp60c-src, tyrosine-protein kinase SRC-1, v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog, ASV, SRC1, THC6, c-SRC, p60-Src,)
• NCBI Gene ID: 6714
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P12931
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

SRC proto-oncogene, non-receptor tyrosine kinase interacts with:

• actin filament associated protein 1
  actin filament associated protein 1 like 2
  acyl-CoA binding domain containing 7
  ADAM metallopeptidase domain 12
  ADAM metallopeptidase domain 15
  adrenergic receptor, beta 3
  ankyrin repeat domain 11
  arachidonate lipoxygenase 3
  ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
  ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
  ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
  autophagy related 9A
  BCAR1 scaffold protein, Cas family member
  BRCA2 and CDKN1A interacting protein
  Cbl proto-oncogene C
  Cbl proto-oncogene like 1
  CD2 associated protein
  CEA cell adhesion molecule 21
  cell division cycle 37, HSP90 cochaperone
  Coenzyme A synthase
  coiled-coil domain containing 8
  complement C1q like 4
  contactin associated protein 1
  coronin 7
  CUB domain containing protein 1
  cyclin A1
  cyclin L2
  cytochrome P450 family 2 subfamily S member 1
  DEAD-box helicase 4
  DExD/H-box helicase 58
  DExH-box helicase 57
  diacylglycerol kinase zeta
  docking protein 2
  docking protein 4
  dual adaptor of phosphotyrosine and 3-phosphoinositides 1
  egl-9 family hypoxia inducible factor 1
  embryonal Fyn-associated substrate
  Enah/Vasp-like
  ERBB receptor feedback inhibitor 1
  F-box protein 5
  FERM, ARH/RhoGEF and pleckstrin domain protein 2
  fermitin family member 2
  fibroblast growth factor receptor substrate 2
  fibronectin type III and SPRY domain containing 1
  forty-two-three domain containing 1
  four and a half LIM domains 1
  GIT ArfGAP 1
  glutaredoxin 3
  GRB2 associated binding protein 2
  GRB2 associated binding protein 3
  histone deacetylase 3
  HNF1 homeobox A
  inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
  interleukin 36 receptor antagonist
  IQ motif containing GTPase activating protein 1
  KH RNA binding domain containing, signal transduction associated 1
  kinesin associated protein 3
  large tumor suppressor kinase 1
  large tumor suppressor kinase 2
  ligand of numb-protein X 1
  mediator complex subunit 21
  mediator complex subunit 28
  microtubule associated monooxygenase, calponin and LIM domain containing 1
  microtubule associated protein 1 light chain 3 beta
  microtubule associated protein RP/EB family member 1
  mitochondrial antiviral signaling protein
  mitogen-activated protein kinase 15
  mitogen-activated protein kinase 8 interacting protein 3
  myelin basic protein
  myelin protein zero like 1
  Nedd4 family interacting protein 2
  nicastrin
  NLR family pyrin domain containing 3
  nuclear receptor coactivator 6
  nuclear receptor subfamily 1 group I member 2
  nuclear receptor subfamily 1 group I member 3
  osteoclast stimulating factor 1
  OTU deubiquitinase with linear linkage specificity like
  PDLIM1 interacting kinase 1 like
  PDZ binding kinase
  PHD finger protein 19
  phosphatidylinositol-4-phosphate 5-kinase type 1 gamma
  phosphoinositide-3-kinase regulatory subunit 3
  phosphoprotein membrane anchor with glycosphingolipid microdomains 1
  pleckstrin homology like domain family A member 2
  potassium voltage-gated channel subfamily Q member 5
  PPARG coactivator 1 beta
  PR/SET domain 2
  programmed cell death 6 interacting protein
  proline, glutamate and leucine rich protein 1
  prominin 1
  protein tyrosine phosphatase non-receptor type 18
  protein tyrosine phosphatase non-receptor type 21
  prune homolog 2 with BCH domain
  RAN binding protein 9
  receptor for activated C kinase 1
  Rho GTPase activating protein 17
  Rho GTPase activating protein 32
  serum response factor
  SH2 domain containing 2A
  SH2 domain containing 3C
  SH3 and PX domains 2A
  SH3 domain binding protein 1
  SH3 domain containing kinase binding protein 1
  signal transducer and activator of transcription 1
  signal transducer and activator of transcription 3
  signal transducer and activator of transcription 5A
  signal transducer and activator of transcription 5B
  signal transducer and activator of transcription 6
  signal transducing adaptor family member 2
  solute carrier family 25 member 41
  sorbin and SH3 domain containing 1
  sphingosine kinase 1
  sphingosine-1-phosphate receptor 2
  spleen associated tyrosine kinase
  src kinase associated phosphoprotein 1
  src kinase associated phosphoprotein 2
  SRC kinase signaling inhibitor 1
  SRC proto-oncogene, non-receptor tyrosine kinase
  SRSF protein kinase 2
  STIP1 homology and U-box containing protein 1
  synapsin I
  T cell receptor associated transmembrane adaptor 1
  talin 1
  TANK binding kinase 1
  target of myb1 like 1 membrane trafficking protein
  telomerase reverse transcriptase
  thymopoietin
  thyroid hormone receptor alpha
  thyroid hormone receptor beta
  thyroid hormone receptor interactor 10
  thyroid hormone receptor interactor 6
  TIAM Rac1 associated GEF 1
  TNF alpha induced protein 3
  TNF receptor associated factor 1
  TNF receptor associated factor 3
  TNF receptor associated factor 6
  TNF receptor superfamily member 11a
  TNF receptor superfamily member 1A
  TNF superfamily member 11
  toll like receptor 4
  toll like receptor 9
  trafficking regulator and scaffold protein tamalin
  transient receptor potential cation channel subfamily C member 6
  transient receptor potential cation channel subfamily V member 4
  transmembrane protein 185A
  transmembrane protein 220
  tripartite motif containing 15
  tripartite motif containing 25
  tripartite motif containing 50
  TUB bipartite transcription factor
  tumor protein p53
  TXK tyrosine kinase
  TYRO3 protein tyrosine kinase
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
  tyrosine kinase non receptor 2
  ubiquitin specific peptidase 8
  villin 1
  vinculin
  vitamin D receptor
  voltage dependent anion channel 3
  WASP actin nucleation promoting factor
  WASP like actin nucleation promoting factor
  WW domain binding protein 11
  WW domain containing oxidoreductase
  YTH domain containing 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.