PROM1, prominin 1

PROM1, prominin 1

• This gene encodes a pentaspan transmembrane glycoprotein. The protein localizes to membrane protrusions and is often expressed on adult stem cells, where it is thought to function in maintaining stem cell properties by suppressing differentiation. Mutations in this gene have been shown to result in retinitis pigmentosa and Stargardt disease. Expression of this gene is also associated with several types of cancer. This gene is expressed from at least five alternative promoters that are expressed in a tissue-dependent manner. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

• Gene Synonyms (prominin-1, antigen AC133, hProminin, hematopoietic stem cell antigen, prominin-like protein 1, AC133, CD133, CORD12, MCDR2, MSTP061, PROML1, RP41, STGD4,)
• NCBI Gene ID: 8842
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A0A0N0M1
  UNIPROT ID#>>O43490
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

prominin 1 interacts with:

• cadherin related family member 1
  histone deacetylase 6
  pleckstrin homology domain containing A5
  synaptojanin 2 binding protein
  translocase of outer mitochondrial membrane 22

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.