TNFRSF11A, TNF receptor superfamily member 11a

TNFRSF11A, TNF receptor superfamily member 11a

• The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptors can interact with various TRAF family proteins, through which this receptor induces the activation of NF-kappa B and MAPK8/JNK. This receptor and its ligand are important regulators of the interaction between T cells and dendritic cells. This receptor is also an essential mediator for osteoclast and lymph node development. Mutations at this locus have been associated with familial expansile osteolysis, autosomal recessive osteopetrosis, and Paget disease of bone. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Aug 2012]

• Gene Synonyms (tumor necrosis factor receptor superfamily member 11A, Paget disease of bone 2, loss of heterozygosity, 18, chromosomal region 1, osteoclast differentiation factor receptor, receptor activator of NF-KB, receptor activator of nuclear factor-kappa B, tumor necrosis factor receptor superfamily, member 11a, NFKB activator, CD265, FEO, LOH18CR1, ODFR, OFE, OPTB7, OSTS, PDB2, RANK, TRANCER,)
• NCBI Gene ID: 8792
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9Y6Q6
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

TNF receptor superfamily member 11a interacts with:

• GRB2 associated binding protein 2
  nuclear RNA export factor 1
  receptor for activated C kinase 1
  TGF-beta activated kinase 1 (MAP3K7) binding protein 2
  TNF receptor-associated factor 5
  vav guanine nucleotide exchange factor 3

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.