PRUNE2, prune homolog 2 with BCH domain

PRUNE2, prune homolog 2 with BCH domain

• The protein encoded by this gene belongs to the B-cell CLL/lymphoma 2 and adenovirus E1B 19 kDa interacting family, whose members play roles in many cellular processes including apotosis, cell transformation, and synaptic function. Several functions for this protein have been demonstrated including suppression of Ras homolog family member A activity, which results in reduced stress fiber formation and suppression of oncogenic cellular transformation. A high molecular weight isoform of this protein has also been shown to colocalize with Adaptor protein complex 2, beta-Adaptin and endodermal markers, suggesting an involvement in post-endocytic trafficking. In prostate cancer cells, this gene acts as a tumor suppressor and its expression is regulated by prostate cancer antigen 3, a non-protein coding gene on the opposite DNA strand in an intron of this gene. Prostate cancer antigen 3 regulates levels of this gene through formation of a double-stranded RNA that undergoes adenosine deaminase actin on RNA-dependent adenosine-to-inosine RNA editing. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]

• Gene Synonyms (protein prune homolog 2, BCH motif-containing molecule at the carboxyl terminal region 1, BNIP2 motif containing molecule at the carboxyl terminal region 1, BNIP2 motif-containing molecule at the C-terminal region 1, olfaxin, truncated PRUNE2, BMCC1, BNIPXL, C9orf65, KIAA0367,)
• NCBI Gene ID: 158471
• Species: Homo sapiens (Human)
• UNIPROT ID#>>D6RTK6
  UNIPROT ID#>>Q5JUB8
  UNIPROT ID#>>B4DSQ3
  UNIPROT ID#>>G8XWS8
  UNIPROT ID#>>B4DJW7
  UNIPROT ID#>>A0A088AWP5
  UNIPROT ID#>>Q8WUY3
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

prune homolog 2 with BCH domain interacts with:

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