SYK, spleen associated tyrosine kinase

SYK, spleen associated tyrosine kinase

• This gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

• Gene Synonyms (tyrosine-protein kinase SYK, spleen tyrosine kinase, p72-Syk,)
• NCBI Gene ID: 6850
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A024R273
  UNIPROT ID#>>P43405
  UNIPROT ID#>>A0A024R244
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

spleen associated tyrosine kinase interacts with:

• autophagy related 16 like 1
  B cell linker
  bromodomain containing 7
  Casitas B-lineage lymphoma
  Coenzyme A synthase
  dipeptidyl peptidase 9
  drebrin like
  ezrin
  Fc receptor like 3
  GRB2 associated binding protein 2
  GRB2 related adaptor protein 2
  hepatocyte growth factor-regulated tyrosine kinase substrate
  histone deacetylase 3
  histone deacetylase 4
  histone deacetylase 6
  histone deacetylase 9
  interleukin 17 receptor A
  linker for activation of T cells
  lymphocyte transmembrane adaptor 1
  mitogen-activated protein kinase kinase kinase 7
  mitogen-activated protein kinase kinase kinase kinase 1
  multiple EGF like domains 10
  NFAT activating protein with ITAM motif 1
  phosphoinositide-3-kinase adaptor protein 1
  phosphoprotein membrane anchor with glycosphingolipid microdomains 1
  platelet endothelial aggregation receptor 1
  pleckstrin homology domain containing A4
  ras homolog family member U
  SEC23 homolog B, COPII coat complex component
  SH2 domain containing 2A
  SH2B adaptor protein 2
  signal regulatory protein beta 1
  signaling threshold regulating transmembrane adaptor 1
  spleen associated tyrosine kinase
  TANK binding kinase 1
  telomeric repeat binding factor 1
  terminal nucleotidyltransferase 5A
  TNF receptor associated factor 3
  TNF receptor associated factor 6
  TNF receptor superfamily member 1A
  toll like receptor 3
  toll like receptor 4
  toll like receptor 9
  toll like receptor adaptor molecule 1
  TRAF interacting protein
  TRAF3 interacting protein 2
  trafficking regulator and scaffold protein tamalin
  transmembrane immune signaling adaptor TYROBP
  tripartite motif containing 15
  tubulin alpha 1a
  tubulin alpha 4a
  tubulin beta class I
  tubulin gamma 1
  tumor protein p53
  ubiquitin associated and SH3 domain containing B
  ubiquitin B
  ubiquitin specific peptidase 25
  vascular cell adhesion molecule 1
  vav guanine nucleotide exchange factor 1
  vav guanine nucleotide exchange factor 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.