BLNK, B cell linker

BLNK, B cell linker

• This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2012]

• Gene Synonyms (B-cell linker protein, B cell adaptor containing SH2 domain, B-cell activation, B-cell adapter containing a SH2 domain protein, B-cell adapter containing a Src homology 2 domain protein, Src homology 2 domain-containing leukocyte protein of 65 kDa, Src homology [SH2] domain-containing leukocyte protein of 65 kD, cytoplasmic adapter protein, AGM4, BASH, BLNK-S, LY57, SLP-65, SLP65, bca,)
• NCBI Gene ID: 29760
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q8WV28
  UNIPROT ID#>>Q2MD54
  UNIPROT ID#>>Q2MD59
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

B cell linker interacts with:

• CKLF like MARVEL transmembrane domain containing 3
  C-type lectin domain containing 17A
  docking protein 3
  SH3 domain containing kinase binding protein 1
  WD repeat domain 81

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.