TYROBP, transmembrane immune signaling adaptor TYROBP

TYROBP, transmembrane immune signaling adaptor TYROBP

• This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. Multiple alternative transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Mar 2010]

• Gene Synonyms (TYRO protein tyrosine kinase-binding protein, DNAX adaptor protein 12, DNAX-activation protein 12, KAR-associated protein, TYRO protein tyrosine kinase binding protein, killer-activating receptor-associated protein, polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy, DAP12, KARAP, PLOSL, PLOSL1,)
• NCBI Gene ID: 7305
• Species: Homo sapiens (Human)
• UNIPROT ID#>>X6RGC9
  UNIPROT ID#>>O43914
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

transmembrane immune signaling adaptor TYROBP interacts with:

• CD300e molecule
  C-type lectin domain containing 5A
  killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 2
  killer cell lectin like receptor C4
  killer cell lectin like receptor K1
  natural cytotoxicity triggering receptor 2
  sialic acid binding Ig like lectin 14
  signal regulatory protein beta 1
  solute carrier family 35 member B4
  transmembrane protein 86A
  triggering receptor expressed on myeloid cells 1
  triggering receptor expressed on myeloid cells 2
  zeta chain of T cell receptor associated protein kinase 70

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