SH2B2, SH2B adaptor protein 2

SH2B2, SH2B adaptor protein 2

• The protein encoded by this gene is expressed in B lymphocytes and contains pleckstrin homology and src homology 2 (SH2) domains. In Burkitt's lymphoma cell lines, it is tyrosine-phosphorylated in response to B cell receptor stimulation. Because it binds Shc independent of stimulation and Grb2 after stimulation, it appears to play a role in signal transduction from the receptor to the Shc/Grb2 pathway. [provided by RefSeq, Jun 2009]

• Gene Synonyms (APS, SH2B adapter protein 2, SH2 and PH domain-containing adapter protein APS, adapter protein with pleckstrin homology and Src homology 2 domains,)
• NCBI Gene ID: 10603
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A0A0MTI2
  UNIPROT ID#>>O14492
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

SH2B adaptor protein 2 interacts with:

• ankyrin repeat and SOCS box containing 6
  dual specificity phosphatase 13
  family with sequence similarity 124 member B
  family with sequence similarity 90 member A1
  interleukin 36 receptor antagonist
  LIM domain only 3
  MAGE family member H1
  metadherin
  pleckstrin homology domain containing A3
  RAB6B, member RAS oncogene family
  SH2B adaptor protein 1
  SH2B adaptor protein 2
  talin rod domain containing 1
  WD repeat domain 83
  zinc finger protein 414
  zinc finger protein 417

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.