Skip Navigation Links Home » Resources » Gene Detail

NR1I2, nuclear receptor subfamily 1 group I member 2

Request a Custom Clone

Don't see what you need?

Request My Custom Clone »
  • Gene Overview
  • Interaction Network
  • Sequence Verification

NR1I2, nuclear receptor subfamily 1 group I member 2

  • This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized. [provided by RefSeq, Jul 2008]

  • Gene Synonyms (nuclear receptor subfamily 1 group I member 2, orphan nuclear receptor PAR1, orphan nuclear receptor PXR, pregnane X nuclear receptor variant 2, pregnane X receptor, steroid and xenobiotic receptor, BXR, ONR1, PAR, PAR1, PAR2, PARq, PRR, PXR, SAR, SXR,)
  • NCBI Gene ID: 8856
  • Species: Homo sapiens (Human)
  • UNIPROT ID#>>F1D8P9
    UNIPROT ID#>>O75469
  • View the NCBI Database for this Gene »

The information on this page was collected from publicly accessible databases, and is periodically updated. Promega makes no claims to accuracy, or ownership of these genes.

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

nuclear receptor subfamily 1 group I member 2 interacts with:

The information on this page was collected from publicly accessible databases, and is periodically updated. Promega makes no claims to accuracy, or ownership of these genes.

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.

The information on this page was collected from publicly accessible databases, and is periodically updated. Promega makes no claims to accuracy, or ownership of these genes.

It appears that you have Javascript disabled. Our website requires Javascript to function correctly. For the best browsing experience, please enable Javascript.