CBLL1, Cbl proto-oncogene like 1

CBLL1, Cbl proto-oncogene like 1

• This gene encodes an E3 ubiquitin-ligase for the E-cadherin complex and mediates its ubiquitination, endocytosis, and degradation in the lysosomes. The encoded protein contains a RING-finger domain and is also thought to have a role in control of cell proliferation. A related pseudogene has been identified on chromosome X. Alternative splicing results in a non-coding transcript variant. [provided by RefSeq, Aug 2011]

• Gene Synonyms (E3 ubiquitin-protein ligase Hakai, Cas-Br-M (murine) ecotropic retroviral transforming sequence-like 1, Cbl proto-oncogene like 1, E3 ubiquitin protein ligase, Cbl proto-oncogene, E3 ubiquitin protein ligase-like 1, E-cadherin binding protein E7, RING finger protein 188, RING-type E3 ubiquitin transferase Hakai, c-Cbl-like protein 1, casitas B-lineage lymphoma-transforming sequence-like protein 1, HAKAI, RNF188,)
• NCBI Gene ID: 79872
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q75N03
  UNIPROT ID#>>B4DDV7
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

Cbl proto-oncogene like 1 interacts with:

• Casitas B-lineage lymphoma-like 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.