SPHK1, sphingosine kinase 1

SPHK1, sphingosine kinase 1

• The protein encoded by this gene catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Intracellularly, S1P regulates proliferation and survival, and extracellularly, it is a ligand for cell surface G protein-coupled receptors. This protein, and its product S1P, play a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes. Phosphorylation of this protein alters its catalytic activity and promotes its translocation to the plasma membrane. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2017]

• Gene Synonyms (sphingosine kinase 1, SK 1, SPK 1, acetyltransferase SPHK1, SPHK,)
• NCBI Gene ID: 8877
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q53ZR5
  UNIPROT ID#>>Q9NYA1
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

sphingosine kinase 1 interacts with:

• dicarbonyl and L-xylulose reductase
  mitogen-activated protein kinase kinase kinase kinase 1
  ribosomal protein S6 kinase C1
  SPHK1 interactor, AKAP domain containing

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.