SKAP2, src kinase associated phosphoprotein 2

SKAP2, src kinase associated phosphoprotein 2

• The protein encoded by this gene shares homology with Src kinase-associated phosphoprotein 1, and is a substrate of Src family kinases. It is an adaptor protein that is thought to play an essential role in the Src signaling pathway, and in regulating proper activation of the immune system. This protein contains an amino terminal coiled-coil domain for self-dimerization, a plecskstrin homology (PH) domain required for interactions with lipids at the membrane, and a Src homology (SH3) domain at the carboxy terminus. Some reports indicate that this protein inhibits actin polymerization through interactions with actin assembly factors, and might negatively regulate the invasiveness of tumors by modulating actin assembly. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2015]

• Gene Synonyms (src kinase-associated phosphoprotein 2, Fyn-associated phosphoprotein SKAP55 homologue, Pyk2/RAFTK-associated protein, SKAP-55HOM, SKAP55 homolog, retinoic acid-induced protein 70, src family-associated phosphoprotein 2, src kinase-associated phosphoprotein of 55-related protein, src-associated adapter protein with PH and SH3 domains, PRAP, RA70, SAPS, SCAP2, SKAP-HOM, SKAP55R,)
• NCBI Gene ID: 8935
• Species: Homo sapiens (Human)
• UNIPROT ID#>>B7Z5R3
  UNIPROT ID#>>O75563
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

src kinase associated phosphoprotein 2 interacts with:

• abhydrolase domain containing 5, lysophosphatidic acid acyltransferase
  family with sequence similarity 102 member A
  FERM domain containing 1
  KH RNA binding domain containing, signal transduction associated 1
  PML-RARA regulated adaptor molecule 1
  src kinase associated phosphoprotein 2

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