DOK2, docking protein 2

DOK2, docking protein 2

• The protein encoded by this gene is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. This encoded protein binds p120 (RasGAP) from CML cells. [provided by RefSeq, Jul 2008]

• Gene Synonyms (docking protein 2, docking protein 2, 56kD, docking protein 2, 56kDa, downstream of tyrosine kinase 2, p56(dok-2), p56DOK, p56dok-2,)
• NCBI Gene ID: 9046
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O60496
  UNIPROT ID#>>B4DKQ6
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

docking protein 2 interacts with:

• adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1
  anti-silencing function 1B histone chaperone
  centromere protein M
  coenzyme Q8A
  DnaJ heat shock protein family (Hsp40) member B11
  docking protein 3
  family with sequence similarity 120B
  heat shock protein family A (Hsp70) member 4 like
  hydrogen voltage gated channel 1
  IQ motif containing F1
  kinesin family binding protein
  LanC like 2
  MINDY lysine 48 deubiquitinase 3
  pleckstrin homology domain containing O1
  protection of telomeres 1
  RAB10, member RAS oncogene family
  transmembrane protein 38A
  zinc ribbon domain containing 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.