BCCIP, BRCA2 and CDKN1A interacting protein

BCCIP, BRCA2 and CDKN1A interacting protein

• This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

• Gene Synonyms (TOK-1, TOK1, BRCA2 and CDKN1A-interacting protein, BCCIPalpha, BCCIPbeta, BRCA2 and Cip1/p21 interacting protein, TOK-1alpha, TOK-1beta, cdk inhibitor p21 binding protein, p21- and CDK-associated protein 1, protein TOK-1,)
• NCBI Gene ID: 56647
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9P287
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

BRCA2 and CDKN1A interacting protein interacts with:

• coiled-coil domain containing 33
  DEAD-box helicase 24
  egl-9 family hypoxia inducible factor 3
  FTO alpha-ketoglutarate dependent dioxygenase
  glutamate rich WD repeat containing 1
  hook microtubule tethering protein 3
  lactate dehydrogenase A like 6B
  MARCKS like 1
  metadherin
  mitochondrial ribosomal protein S9
  NOP9 nucleolar protein
  pleckstrin homology domain containing A4
  ribosomal protein L35
  signal recognition particle 72
  terminal nucleotidyltransferase 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.