POLR1A, RNA polymerase I subunit A

POLR1A, RNA polymerase I subunit A

• The protein encoded by this gene is the largest subunit of the RNA polymerase I complex. The encoded protein represents the catalytic subunit of the complex, which transcribes DNA into ribosomal RNA precursors. Defects in this gene are a cause of the Cincinnati type of acrofacial dysostosis. [provided by RefSeq, May 2016]

• Gene Synonyms (DNA-directed RNA polymerase I subunit RPA1, DNA-directed RNA polymerase I largest subunit, DNA-directed RNA polymerase I subunit A, DNA-directed RNA polymerase I subunit A1, RNA polymerase I 194 kDa subunit, polymerase (RNA) I polypeptide A, 194kDa, polymerase (RNA) I subunit A, A190, AFDCIN, RPA1, RPA194, RPO1-4, RPO14,)
• NCBI Gene ID: 25885
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O95602
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

RNA polymerase I subunit A interacts with:

• ankyrin repeat and SOCS box containing 7
  autophagy related 16 like 1
  coiled-coil domain containing 8
  DPY30 domain containing 2
  galectin 13
  glucose-fructose oxidoreductase domain containing 1
  GPN-loop GTPase 3
  INO80 complex ATPase subunit
  kelch repeat and BTB domain containing 8
  KIAA1522
  leucine rich repeat containing G protein-coupled receptor 4
  limb development membrane protein 1 like
  LINE1 type transposase domain containing 1
  NCK associated protein 5 like
  NOP58 ribonucleoprotein
  p53 and DNA damage regulated 1
  PIH1 domain containing 1
  pleckstrin homology domain containing A4
  RNA polymerase I and III subunit D
  RNA polymerase I subunit B
  RNA polymerase I subunit E
  RNA polymerase I subunit F
  RNA polymerase I subunit H
  RNA polymerase II associated protein 3
  RNA polymerase III subunit B
  RRN3 homolog, RNA polymerase I transcription factor
  sirtuin 7
  SNF2 histone linker PHD RING helicase
  sorting nexin family member 21
  TATA-box binding protein associated factor, RNA polymerase I subunit D
  terminal nucleotidyltransferase 5A
  vir like m6A methyltransferase associated
  WD repeat domain 76
  WD repeat domain 92

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.