PPFIA1, PTPRF interacting protein alpha 1

PPFIA1, PTPRF interacting protein alpha 1

• The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. This protein binds to the intracellular membrane-distal phosphatase domain of tyrosine phosphatase LAR, and appears to localize LAR to cell focal adhesions. This interaction may regulate the disassembly of focal adhesion and thus help orchestrate cell-matrix interactions. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

• Gene Synonyms (liprin-alpha-1, LAR-interacting protein 1, LIP-1, Liprin-alpha1, protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1, protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1, LIP.1, LIP1, LIPRIN,)
• NCBI Gene ID: 8500
• Species: Homo sapiens (Human)
• UNIPROT ID#>>B3KVS8
  UNIPROT ID#>>Q13136
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

PTPRF interacting protein alpha 1 interacts with:

• angiomotin
  ATP/GTP binding protein 1
  aurora kinase B
  cancer antigen 1
  cell division cycle 14A
  centrosomal protein 70
  chromosome 16 open reading frame 70
  coiled-coil domain containing 120
  CTD phosphatase subunit 1
  cytochrome P450 family 4 subfamily X member 1
  DnaJ heat shock protein family (Hsp40) member C5
  drosha ribonuclease III
  egl-9 family hypoxia inducible factor 3
  ELKS/RAB6-interacting/CAST family member 1
  ELKS/RAB6-interacting/CAST family member 2
  exocyst complex component 8
  FAM161 centrosomal protein A
  GIT ArfGAP 1
  glucosylceramidase beta 2
  glutamate receptor interacting protein 2
  inhibitor of growth family member 4
  inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
  interleukin 17 receptor E
  kinesin family member 4
  large tumor suppressor kinase 2
  ligand of numb-protein X 1
  MAP3K12 binding inhibitory protein 1
  nuclear receptor coactivator 2
  pleckstrin homology domain containing A4
  protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform
  protein phosphatase 2, regulatory subunit A, alpha
  PTPRF interacting protein alpha 1
  PTPRF interacting protein alpha 3
  RAB11 family interacting protein 1 (class I)
  syntaxin 11
  taxilin alpha
  tetratricopeptide repeat domain 9B
  TNFAIP3 interacting protein 2
  tumor protein p63
  vir like m6A methyltransferase associated

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.