CCT6A, chaperonin containing TCP1 subunit 6A

CCT6A, chaperonin containing TCP1 subunit 6A

• The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized. In addition, several pseudogenes of this gene have been located. [provided by RefSeq, Jun 2010]

• Gene Synonyms (T-complex protein 1 subunit zeta, T-complex protein 1, zeta subunit, acute morphine dependence related protein 2, amino acid transport defect-complementing, chaperonin containing T-complex subunit 6, chaperonin containing TCP1, subunit 6A (zeta 1), histidine transport regulator 3, CCT-zeta, CCT-zeta-1, CCT6, Cctz, HTR3, MoDP-2, TCP-1-zeta, TCP20, TCPZ, TTCP20,)
• NCBI Gene ID: 908
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P40227
  UNIPROT ID#>>A0A024RDL1
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

chaperonin containing TCP1 subunit 6A interacts with:

• 2'-5'-oligoadenylate synthetase like
  AAR2 splicing factor
  actin beta like 2
  actin related protein 1B
  actin related protein 2
  actin related protein 3
  actin related protein 3B
  activator of HSP90 ATPase activity 1
  alkB homolog 3, alpha-ketoglutarate dependent dioxygenase
  angiopoietin like 7
  anterior gradient 2, protein disulphide isomerase family member
  armadillo repeat containing 6
  ARP1 actin-related protein 1B, centractin beta
  ataxin 3
  B9 domain containing 1
  BCL2-associated athanogene 2
  beta-transducin repeat containing E3 ubiquitin protein ligase
  BUB3 mitotic checkpoint protein
  calmodulin-lysine N-methyltransferase
  carboxypeptidase Z
  cell division cycle 20
  cell division cycle 20
  cell division cycle 5 like
  cell division cycle 73
  centrin 2
  centromere protein F
  cereblon
  chaperonin containing TCP1 subunit 2
  chaperonin containing TCP1 subunit 3
  chaperonin containing TCP1 subunit 4
  chaperonin containing TCP1 subunit 5
  chaperonin containing TCP1 subunit 6B
  chaperonin containing TCP1 subunit 7
  chaperonin containing TCP1 subunit 8
  chaperonin containing Tcp1, subunit 2 (beta)
  chaperonin containing Tcp1, subunit 3 (gamma)
  chaperonin containing Tcp1, subunit 4 (delta)
  chaperonin containing Tcp1, subunit 7 (eta)
  chaperonin containing Tcp1, subunit 8 (theta)
  chromosome 11 open reading frame 54
  cilia and flagella associated protein 52
  clathrin heavy chain
  coiled-coil domain containing 8
  COP1 E3 ubiquitin ligase
  cortactin binding protein 2
  cryptochrome circadian regulator 1
  cryptochrome circadian regulator 2
  cullin 3
  cullin 7
  cyclin dependent kinase 11A
  cyclin dependent kinase 2
  cyclin dependent kinase 5
  CYLD lysine 63 deubiquitinase
  damage specific DNA binding protein 2
  DDB1 and CUL4 associated factor 11
  DDB1 and CUL4 associated factor 5
  DDB1 and CUL4 associated factor 7
  denticleless E3 ubiquitin protein ligase
  DnaJ heat shock protein family (Hsp40) member A1
  DnaJ heat shock protein family (Hsp40) member A4
  dynein 2 intermediate chain 2
  dynein axonemal intermediate chain 2
  dynein cytoplasmic 1 intermediate chain 1
  dynein cytoplasmic 1 intermediate chain 2
  EARP complex and GARP complex interacting protein 1
  EEF1A lysine methyltransferase 3
  egl-9 family hypoxia inducible factor 3
  EH domain containing 2
  electron transfer flavoprotein subunit beta lysine methyltransferase
  elongation factor Tu GTP binding domain containing 2
  embryonic ectoderm development
  enhancer of zeste 2 polycomb repressive complex 2 subunit
  ERCC excision repair 8, CSA ubiquitin ligase complex subunit
  estrogen receptor 2
  eukaryotic translation elongation factor 1 delta
  eukaryotic translation initiation factor 4B
  family with sequence similarity 86 member B2
  fatty acid synthase
  F-box and WD repeat domain containing 11
  F-box and WD repeat domain containing 4
  F-box and WD repeat domain containing 8
  F-box protein 25
  F-box protein 6
  F-box protein 7
  fibronectin 1
  forkhead box A1
  FUS RNA binding protein
  FYVE and coiled-coil domain autophagy adaptor 1
  G protein subunit beta 2
  G3BP stress granule assembly factor 1
  galectin 3 binding protein
  gigaxonin
  glucosidase II alpha subunit
  glutamate rich WD repeat containing 1
  glutamine--fructose-6-phosphate transaminase 1
  glycogen synthase kinase 3 beta
  glypican 1
  GPN-loop GTPase 1
  guanine nucleotide binding protein (G protein), beta 1
  HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
  hes related family bHLH transcription factor with YRPW motif 1
  HEXIM P-TEFb complex subunit 1
  histone deacetylase 1
  histone deacetylase 11
  histone deacetylase 2
  histone deacetylase 3
  histone deacetylase 5
  host cell factor C2
  huntingtin
  hypoxia inducible factor 1 subunit alpha inhibitor
  immunoglobulin binding protein 1
  inhibitor of nuclear factor kappa B kinase subunit epsilon
  integrin alpha FG-GAP repeat containing 1
  integrin linked kinase
  integrin subunit alpha 4
  interferon regulatory factor 7
  interleukin 1 receptor associated kinase 1
  isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha
  Janus kinase 3
  karyopherin subunit alpha 4
  kelch domain containing 2
  kelch domain containing 8A
  kelch like family member 33
  kinase suppressor of ras 1
  kinesin family member 21A
  kinesin family member 21B
  L3MBTL histone methyl-lysine binding protein 2
  La ribonucleoprotein 7, transcriptional regulator
  lactate dehydrogenase B
  leucyl-tRNA synthetase 1
  LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
  ligand dependent nuclear receptor corepressor
  lysine demethylase 4B
  lysyl oxidase like 4
  MDS1 and EVI1 complex locus
  methylphosphate capping enzyme
  methyltransferase like 14
  methyltransferase like 18
  methyltransferase like 3
  methyltransferase like 6
  minichromosome maintenance complex component 2
  mitogen-activated protein kinase 13
  mitogen-activated protein kinase 6
  mitogen-activated protein kinase 8
  MKS transition zone complex subunit 1
  MOB family member 4, phocein
  MYC proto-oncogene, bHLH transcription factor
  myosin XIX
  N-acetyltransferase 16 (putative)
  NEDD1 gamma-tubulin ring complex targeting factor
  neural precursor cell expressed, developmentally down-regulated gene 1
  neurotrophic receptor tyrosine kinase 1
  neutral sphingomyelinase activation associated factor
  nipsnap homolog 1
  nitric oxide synthase 2
  NK2 homeobox 1
  notch receptor 1
  notchless homolog 1
  nuclear receptor subfamily 2 group C member 2
  nuclear transcription factor, X-box binding 1
  obscurin like cytoskeletal adaptor 1
  outer dense fiber of sperm tails 1
  palmitoyl-protein thioesterase 1
  parkin coregulated
  parkin RBR E3 ubiquitin protein ligase
  peroxisomal biogenesis factor 14
  peroxisomal biogenesis factor 7
  phosducin like 3
  phosphatidylinositol 4-kinase type 2 beta
  phosphoethanolamine/phosphocholine phosphatase 1
  PIH1 domain containing 1
  pleckstrin homology domain containing A4
  POC1 centriolar protein A
  polo like kinase 4
  poly(A) specific ribonuclease subunit PAN2
  polycomb group ring finger 3
  polycomb group ring finger 5
  polycomb group ring finger 6
  pre-mRNA processing factor 4
  prohibitin
  prolyl 4-hydroxylase subunit alpha 2
  proteasome 20S subunit alpha 3
  proteasome 26S subunit, ATPase 2
  proteasome 26S subunit, non-ATPase 14
  protein kinase C zeta
  protein kinase N2
  protein phosphatase 1 catalytic subunit alpha
  protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform
  protein phosphatase 2 catalytic subunit alpha
  protein phosphatase 2 catalytic subunit beta
  protein phosphatase 2 phosphatase activator
  protein phosphatase 2 regulatory subunit Balpha
  protein phosphatase 2 regulatory subunit Bbeta
  protein phosphatase 2 regulatory subunit Bdelta
  protein phosphatase 2 regulatory subunit Bgamma
  protein phosphatase 4 catalytic subunit
  protein phosphatase 4, catalytic subunit
  protein phosphatase 6 catalytic subunit
  protein phosphatase 6, catalytic subunit
  PTEN induced kinase 1
  pyruvate carboxylase
  pyruvate dehydrogenase kinase 3
  RAD18 E3 ubiquitin protein ligase
  RAP2A, member of RAS oncogene family
  RAP2B, member of RAS oncogene family
  RAP2C, member of RAS oncogene family
  RecQ like helicase 4
  regulatory associated protein of MTOR complex 1
  ribophorin I
  ribosomal protein S6 kinase B2
  ribosomal protein SA
  ring finger and CCCH-type domains 1
  ring finger and CCCH-type domains 2
  ring finger and WD repeat domain 3
  ring finger protein 31
  RNA polymerase II associated protein 1
  SAMM50 sorting and assembly machinery component
  SEC31 homolog B, COPII coat complex component
  serine/threonine kinase 24
  serum/glucocorticoid regulated kinase 2
  SHC adaptor protein 1
  signal regulatory protein alpha
  SMAD family member 2
  SMAD specific E3 ubiquitin protein ligase 1
  small ubiquitin like modifier 4
  snail family transcriptional repressor 1
  SNW domain containing 1
  solute carrier family 25 member 3
  splicing factor 3b subunit 1
  staufen double-stranded RNA binding protein 1
  striatin
  striatin 3
  striatin, calmodulin binding protein 3
  succinate-CoA ligase GDP-forming subunit beta
  SUMO specific peptidase 2
  suppressor of variegation 3-9 homolog 1
  suppressor of variegation 3-9 homolog 2
  SUZ12 polycomb repressive complex 2 subunit
  t-complex 1
  testis specific serine kinase 6
  tetratricopeptide repeat domain 27
  thioredoxin domain containing 9
  THO complex 3
  trans-2,3-enoyl-CoA reductase
  transcription factor CP2
  transducin beta like 1 Y-linked
  transforming growth factor beta 1
  transmembrane protein 41B
  tripartite motif containing 25
  tripartite motif containing 28
  tripartite motif containing 31
  tubulin alpha 1a
  tubulin alpha 1b
  tubulin alpha 1c
  tubulin alpha like 3
  tubulin beta 2A class IIa
  tubulin beta 2B class IIb
  tubulin gamma 1
  tubulin gamma 2
  tubulin tyrosine ligase like 3
  tubulin, alpha 3A
  tubulin, epsilon 1
  tubulin, gamma 1
  tumor protein p53
  tyrosine kinase 2
  U2 small nuclear RNA auxiliary factor 2
  ubiquilin 2
  ubiquinol-cytochrome c reductase core protein 2
  ubiquitin associated and SH3 domain containing B
  ubiquitin C
  ubiquitin conjugating enzyme E2 A
  ubiquitin conjugating enzyme E2 M
  ubiquitin C-terminal hydrolase L3
  ubiquitin specific peptidase 5
  valosin containing protein
  vascular cell adhesion molecule 1
  vimentin
  vir like m6A methyltransferase associated
  von Hippel-Lindau tumor suppressor
  WD and tetratricopeptide repeats 1
  WD repeat containing antisense to TP53
  WD repeat domain 37
  WD repeat domain 48
  WD repeat domain 5
  WD repeat domain 5B
  WD repeat domain 61
  WD repeat domain 77
  WD repeat domain 83
  WD repeat domain 86
  WD repeat domain 92
  WW domain containing oxidoreductase
  X-ray repair cross complementing 3
  Yes1 associated transcriptional regulator
  zinc finger and BTB domain containing 7A
  zinc finger protein 598, E3 ubiquitin ligase
  zinc finger protein 746

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.