ERCC8, ERCC excision repair 8, CSA ubiquitin ligase complex subunit

ERCC8, ERCC excision repair 8, CSA ubiquitin ligase complex subunit

• This gene encodes a WD repeat protein, which interacts with Cockayne syndrome type B (CSB) protein and with p44 protein, a subunit of the RNA polymerase II transcription factor IIH. Mutations in this gene have been identified in patients with hereditary disease Cockayne syndrome (CS). CS cells are abnormally sensitive to ultraviolet radiation and are defective in the repair of transcriptionally active genes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2014]

• Gene Synonyms (DNA excision repair protein ERCC-8, Cockayne syndrome WD-repeat protein CSA, cockayne syndrome WD repeat protein CSA, excision repair cross-complementation group 8, excision repair cross-complementing rodent repair deficiency, complementation group 8, CKN1, CSA, UVSS2,)
• NCBI Gene ID: 1161
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A0S2Z3L1
  UNIPROT ID#>>B3KPW7
  UNIPROT ID#>>B4DGZ9
  UNIPROT ID#>>Q13216
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

ERCC excision repair 8, CSA ubiquitin ligase complex subunit interacts with:

• 8-oxoguanine DNA glycosylase
  BAG cochaperone 2
  BCL6 corepressor
  casein kinase 2 beta
  chaperonin containing TCP1 subunit 2
  chaperonin containing TCP1 subunit 3
  chaperonin containing TCP1 subunit 4
  chaperonin containing TCP1 subunit 5
  chaperonin containing TCP1 subunit 7
  chaperonin containing TCP1 subunit 8
  COP1 E3 ubiquitin ligase
  COP9 signalosome subunit 2
  COP9 signalosome subunit 3
  COP9 signalosome subunit 4
  COP9 signalosome subunit 5
  COP9 signalosome subunit 6
  COP9 signalosome subunit 7A
  COP9 signalosome subunit 7B
  COP9 signalosome subunit 8
  cullin 4A
  cullin 4B
  cullin 5
  damage specific DNA binding protein 1
  damage specific DNA binding protein 1
  damage specific DNA binding protein 2
  DET1 and DDB1 associated 1
  developmental pluripotency associated 4
  DNA topoisomerase I
  DnaJ heat shock protein family (Hsp40) member A1
  DnaJ heat shock protein family (Hsp40) member A2
  DnaJ heat shock protein family (Hsp40) member B4
  dynamin 1 like
  E1A binding protein p300
  ERCC excision repair 6, chromatin remodeling factor
  G protein pathway suppressor 1
  general transcription factor IIH subunit 2
  H1.0 linker histone
  heat shock protein family A (Hsp70) member 1B
  heat shock protein family A (Hsp70) member 2
  heat shock protein family A (Hsp70) member 8
  heat shock protein family D (Hsp60) member 1
  high mobility group nucleosome binding domain 1
  MDM2 proto-oncogene
  Nanog homeobox
  polycomb group ring finger 1
  POU class 5 homeobox 1
  prefoldin subunit 1
  prefoldin subunit 2
  prefoldin subunit 4
  prefoldin subunit 5
  prefoldin subunit 6
  proliferating cell nuclear antigen
  proteasome 20S subunit beta 5
  proteasome 26S subunit, non-ATPase 1
  ring-box 1
  RNA polymerase II subunit A
  RuvB like AAA ATPase 2
  single stranded DNA binding protein 1
  t-complex 1
  tripartite motif containing 25
  tumor protein p53
  ubiquinol-cytochrome c reductase complex III subunit VII
  ubiquitin conjugating enzyme E2 M
  UBX domain protein 7
  UV stimulated scaffold protein A
  valosin containing protein
  XPA binding protein 2
  zinc finger protein 24

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.