TOP1, DNA topoisomerase I

TOP1, DNA topoisomerase I

• This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus altering the topology of DNA. This gene is localized to chromosome 20 and has pseudogenes which reside on chromosomes 1 and 22. [provided by RefSeq, Jul 2008]

• Gene Synonyms (DNA topoisomerase 1, Scl-70 antigen, topoisomerase (DNA) I, type I DNA topoisomerase, TOPI,)
• NCBI Gene ID: 7150
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P11387
  UNIPROT ID#>>Q9BVT2
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

DNA topoisomerase I interacts with:

• anterior gradient 2, protein disulphide isomerase family member
  aprataxin and PNKP like factor
  AT-rich interaction domain 1A
  autophagy related 16 like 1
  bromodomain containing 7
  BTB domain containing 1
  BTB domain containing 2
  BUB3 mitotic checkpoint protein
  cap methyltransferase 1
  cell death inducing DFFA like effector c
  cell division cycle 73
  chromatin licensing and DNA replication factor 1
  COP9 signalosome subunit 5
  cullin 1
  cullin 3
  cullin 7
  cullin associated and neddylation dissociated 1
  cytoskeleton associated protein 5
  DEAD-box helicase 17
  DEAD-box helicase 23
  decapping enzyme, scavenger
  DExD-box helicase 21
  dihydrouridine synthase 4 like
  DISC1 scaffold protein
  DNA topoisomerase I
  DNA topoisomerase II alpha
  DNA topoisomerase II beta
  ELL associated factor 1
  elongation factor Tu GTP binding domain containing 2
  embryonic ectoderm development
  endothelial cell adhesion molecule
  F-box and WD repeat domain containing 7
  gem nuclear organelle associated protein 4
  glutamate rich WD repeat containing 1
  H1.10 linker histone
  H3 clustered histone 1
  H3 clustered histone 6
  H4 clustered histone 1
  HECT and RLD domain containing E3 ubiquitin protein ligase 2
  heterogeneous nuclear ribonucleoprotein A3
  heterogeneous nuclear ribonucleoprotein R
  HEXIM P-TEFb complex subunit 1
  histone deacetylase 5
  histone deacetylase 9
  interferon regulatory factor 9
  La ribonucleoprotein 7, transcriptional regulator
  LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated
  macroH2A.1 histone
  metadherin
  methylphosphate capping enzyme
  N-acetyltransferase 10
  nicastrin
  NLR family pyrin domain containing 3
  NOP56 ribonucleoprotein
  nuclear receptor binding SET domain protein 2
  nuclear receptor coactivator 6
  nuclear receptor subfamily 2 group C member 2
  obscurin like cytoskeletal adaptor 1
  partner and localizer of BRCA2
  pescadillo ribosomal biogenesis factor 1
  phosphodiesterase 10A
  Pim-2 proto-oncogene, serine/threonine kinase
  pleckstrin homology domain containing A4
  polybromo 1
  potassium channel modulatory factor 1
  PR/SET domain 16
  pre-mRNA processing factor 8
  PWP1 homolog, endonuclein
  RAD18 E3 ubiquitin protein ligase
  ribosomal RNA processing 1B
  ring finger and CCCH-type domains 1
  ring finger protein 181
  RNA binding motif protein 14
  RNA binding motif protein 25
  RNA binding motif protein 28
  RNA binding motif protein 39
  SEM1 26S proteasome complex subunit
  serine and arginine rich splicing factor 11
  sirtuin 7
  small nuclear ribonucleoprotein U5 subunit 200
  small ubiquitin like modifier 1
  SNW domain containing 1
  splicing factor 3b subunit 1
  splicing factor 3b subunit 3
  splicing factor 3b subunit 6
  SPT16 homolog, facilitates chromatin remodeling subunit
  symplekin
  TAR DNA binding protein
  titin
  TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase
  TRAF interacting protein
  translocated promoter region, nuclear basket protein
  tripartite motif containing 25
  tripartite motif containing 26
  tripartite motif containing 28
  tripartite motif containing 32
  TSC complex subunit 1
  tubulin delta 1
  tumor protein p53
  tumor protein, translationally-controlled 1
  tyrosyl-DNA phosphodiesterase 1
  U2 small nuclear RNA auxiliary factor 2
  ubiquitin conjugating enzyme E2 I
  ubiquitin C-terminal hydrolase L3
  ubiquitin protein ligase E3C
  ubiquitin specific peptidase 14
  UTP20 small subunit processome component
  valosin containing protein
  vascular cell adhesion molecule 1
  vir like m6A methyltransferase associated
  voltage dependent anion channel 1
  WEE1 G2 checkpoint kinase
  WW domain containing E3 ubiquitin protein ligase 2
  X-ray repair cross complementing 5
  zinc finger RANBP2-type containing 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.