TPR, translocated promoter region, nuclear basket protein

TPR, translocated promoter region, nuclear basket protein

• This gene encodes a large coiled-coil protein that forms intranuclear filaments attached to the inner surface of nuclear pore complexes (NPCs). The protein directly interacts with several components of the NPC. It is required for the nuclear export of mRNAs and some proteins. Oncogenic fusions of the 5' end of this gene with several different kinase genes occur in some neoplasias. [provided by RefSeq, Jul 2008]

• Gene Synonyms (nucleoprotein TPR, NPC-associated intranuclear protein, megator, nuclear pore complex-associated protein TPR, translocated promoter region (to activated MET oncogene), translocated promoter region protein, tumor potentiating region,)
• NCBI Gene ID: 7175
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P12270
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

translocated promoter region, nuclear basket protein interacts with:

• atlastin GTPase 3
  BUD31 homolog
  checkpoint kinase 2
  chromobox 7
  coiled-coil domain containing 8
  cullin 7
  decapping enzyme, scavenger
  dual specificity phosphatase 19
  elongation factor Tu GTP binding domain containing 2
  embryonic ectoderm development
  golgi brefeldin A resistant guanine nucleotide exchange factor 1
  H3 clustered histone 1
  histone deacetylase 4
  histone deacetylase 9
  katanin p60 (ATPase-containing) subunit A1
  kinesin family member C5B
  leucine rich repeat containing G protein-coupled receptor 4
  leucine rich repeat kinase 2
  lysine acetyltransferase 8
  MAD2 mitotic arrest deficient-like 1
  mitotic arrest deficient 1 like 1
  nuclear receptor binding SET domain protein 2
  nuclear receptor coactivator 3
  nuclear RNA export factor 1
  nucleoporin 107
  nucleoporin 153
  nucleoporin 205
  nucleoporin 93
  nucleoporin 98
  obscurin like cytoskeletal adaptor 1
  PCNA clamp associated factor
  pleckstrin homology domain containing A4
  ribosomal RNA processing 12 homolog
  ribosomal RNA processing 7 homolog A
  ribosome biogenesis regulator 1 homolog
  serine and arginine rich splicing factor 11
  Sin3A associated protein 18
  sirtuin 7
  spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP
  spliceosome associated factor 3, U4/U6 recycling protein
  splicing factor 3b subunit 6
  stress induced phosphoprotein 1
  TATA-box binding protein associated factor 15
  thioredoxin interacting protein
  THO complex 6
  TNFAIP3 interacting protein 2
  trans-golgi network protein 2
  translocated promoter region, nuclear basket protein
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
  U2 small nuclear RNA auxiliary factor 2
  ubiquitin conjugating enzyme E2 A
  vir like m6A methyltransferase associated
  zinc finger C3HC-type containing 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.