XRCC3, X-ray repair cross complementing 3

XRCC3, X-ray repair cross complementing 3

• This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene functionally complements Chinese hamster irs1SF, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents and is chromosomally unstable. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

• Gene Synonyms (DNA repair protein XRCC3, X-ray repair complementing defective repair in Chinese hamster cells 3, X-ray repair cross-complementing protein 3, CMM6,)
• NCBI Gene ID: 7517
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q53XC8
  UNIPROT ID#>>O43542
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

X-ray repair cross complementing 3 interacts with:

• angiogenic factor with G-patch and FHA domains 1
  BCAS3 microtubule associated cell migration factor
  BRCA1 associated protein 1
  calcium homeostasis endoplasmic reticulum protein
  cell division cycle and apoptosis regulator 1
  chaperonin containing TCP1 subunit 8
  choline/ethanolamine phosphotransferase 1
  chromosome 17 open reading frame 49
  chromosome transmission fidelity factor 18
  coiled-coil domain containing 124
  complement component 5a receptor 2
  COPI coat complex subunit epsilon
  cytoskeleton associated protein 4
  derlin 1
  DnaJ heat shock protein family (Hsp40) member C8
  ER lipid raft associated 1
  Era like 12S mitochondrial rRNA chaperone 1
  erbb2 interacting protein
  eukaryotic translation initiation factor 2B subunit delta
  eukaryotic translation initiation factor 3 subunit A
  eukaryotic translation initiation factor 3 subunit F
  eukaryotic translation initiation factor 5B
  exocyst complex component 6
  FKBP prolyl isomerase 8
  GCN1 activator of EIF2AK4
  gem nuclear organelle associated protein 7
  glycosylated lysosomal membrane protein
  GPN-loop GTPase 1
  growth regulating estrogen receptor binding 1
  HCLS1 associated protein X-1
  HDGF like 2
  hook microtubule tethering protein 2
  importin 9
  inhibitory synaptic factor 2A
  inter-alpha-trypsin inhibitor heavy chain 5
  junctophilin 1
  listerin E3 ubiquitin protein ligase 1
  LRAT domain containing 2
  lysosomal associated membrane protein 3
  mannose receptor C type 2
  mediator complex subunit 16
  mediator complex subunit 17
  mediator complex subunit 24
  MMS19 homolog, cytosolic iron-sulfur assembly component
  myoferlin
  nicalin
  non-SMC condensin II complex subunit D3
  nuclear export mediator factor
  nuclear receptor coactivator 4
  nuclear speckle splicing regulatory protein 1
  nucleoporin 93
  oxidative stress induced growth inhibitor 1
  partner and localizer of BRCA2
  peptidylprolyl isomerase like 4
  PEST proteolytic signal containing nuclear protein
  phosphoinositide-3-kinase regulatory subunit 4
  pleckstrin homology domain containing A4
  potassium channel tetramerization domain containing 10
  prohibitin 2
  PSMC3 interacting protein
  reticulocalbin 3
  ring finger protein 20
  RIO kinase 3
  RNA binding motif protein 10
  RNA binding motif protein 17
  RNA binding motif protein 5
  secretoglobin family 3A member 1
  secretory carrier membrane protein 3
  sideroflexin 1
  sideroflexin 3
  solute carrier family 25 member 13
  solute carrier organic anion transporter family member 4A1
  spermatogenesis associated 5 like 1
  splicing factor 3a subunit 1
  splicing factor 3b subunit 1
  splicing factor 3b subunit 2
  SSX family member 2 interacting protein
  stress induced phosphoprotein 1
  sulfide quinone oxidoreductase
  SWIM-type zinc finger 7 associated protein 1
  tankyrase 1 binding protein 1
  torsin 1A interacting protein 2
  trans-2,3-enoyl-CoA reductase
  translocase of inner mitochondrial membrane 13
  translocase of outer mitochondrial membrane 22
  tripartite motif containing 25
  tryptase beta 2
  tubulin alpha 1a
  ubiquinol-cytochrome c reductase complex III subunit VII
  ubiquitin protein ligase E3 component n-recognin 4
  ubiquitin protein ligase E3 component n-recognin 5
  unc-45 myosin chaperone A
  V-set and immunoglobulin domain containing 4
  zinc finger CCCH-type containing 11A
  zinc finger HIT-type containing 3
  zinc finger protein 598, E3 ubiquitin ligase
  zinc finger SWIM-type containing 7
  zw10 kinetochore protein

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.