UBA1, ubiquitin like modifier activating enzyme 1

UBA1, ubiquitin like modifier activating enzyme 1

• The protein encoded by this gene catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation. This gene complements an X-linked mouse temperature-sensitive defect in DNA synthesis, and thus may function in DNA repair. It is part of a gene cluster on chromosome Xp11.23. Alternatively spliced transcript variants that encode the same protein have been described. [provided by RefSeq, Jul 2008]

• Gene Synonyms (ubiquitin-like modifier-activating enzyme 1, A1S9T and BN75 temperature sensitivity complementing, POC20 centriolar protein homolog, UBA1, ubiquitin-activating enzyme E1 homolog A, testicular secretory protein Li 63, A1S9, A1S9T, A1ST, AMCX1, CFAP124, GXP1, POC20, SMAX2, UBA1A, UBE1, UBE1X,)
• NCBI Gene ID: 7317
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A024R1A3
  UNIPROT ID#>>P22314
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

ubiquitin like modifier activating enzyme 1 interacts with:

• 2'-deoxynucleoside 5'-phosphate N-hydrolase 1
  AAR2 splicing factor
  activator of HSP90 ATPase activity 1
  adaptor related protein complex 1 subunit mu 1
  alanyl-tRNA synthetase 2, mitochondrial
  aminoacyl tRNA synthetase complex interacting multifunctional protein 2
  armadillo repeat containing 6
  autophagy related 16 like 1
  BAG cochaperone 3
  BUB3 mitotic checkpoint protein
  cell division cycle 73
  centrosomal protein 290
  chromosome transmission fidelity factor 8
  coiled-coil domain containing 8
  COP9 signalosome subunit 5
  cullin 3
  cullin 7
  cytokine induced apoptosis inhibitor 1
  diablo IAP-binding mitochondrial protein
  dipeptidyl peptidase 3
  dynamin 1 like
  EEF1A lysine methyltransferase 3
  elongation factor Tu GTP binding domain containing 2
  ER degradation enhancing alpha-mannosidase like protein 3
  eukaryotic translation elongation factor 1 epsilon 1
  expressed sequence AI837181
  ezrin
  F-box and WD repeat domain containing 11
  G3BP stress granule assembly factor 1
  gigaxonin
  glutamate rich WD repeat containing 1
  GrpE like 1, mitochondrial
  guanine deaminase
  H4 clustered histone 1
  heat shock protein family H (Hsp110) member 1
  HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
  hepatocyte growth factor-regulated tyrosine kinase substrate
  HEXIM P-TEFb complex subunit 1
  histone deacetylase 5
  hypoxia inducible factor 1 subunit alpha inhibitor
  inhibitor of Bruton tyrosine kinase
  isoleucyl-tRNA synthetase 2, mitochondrial
  itchy E3 ubiquitin protein ligase
  leucine carboxyl methyltransferase 2
  leucyl-tRNA synthetase 1
  MCTS1 re-initiation and release factor
  mex-3 RNA binding family member C
  mitogen-activated protein kinase 13
  myotrophin
  NMD3 ribosome export adaptor
  NOP2/Sun RNA methyltransferase 2
  NPL4 homolog, ubiquitin recognition factor
  nucleoporin 93
  obscurin like cytoskeletal adaptor 1
  phosphoethanolamine/phosphocholine phosphatase 1
  PIH1 domain containing 1
  pleckstrin homology domain containing A4
  poly(A) binding protein cytoplasmic 1
  progesterone receptor membrane component 1
  programmed cell death 6 interacting protein
  proteasome 26S subunit, non-ATPase 14
  protein inhibitor of activated STAT 3
  protein phosphatase targeting COQ7
  PTEN induced kinase 1
  quinolinate phosphoribosyltransferase
  receptor interacting serine/threonine kinase 4
  RecQ like helicase 4
  RIC8 guanine nucleotide exchange factor A
  septin 6
  SET binding factor 2
  suppressor APC domain containing 2
  taxilin gamma
  tetratricopeptide repeat domain 19
  thyroid hormone receptor interactor 13
  translocase of inner mitochondrial membrane 44
  transmembrane and coiled-coil domain family 2
  tripartite motif containing 25
  tumor suppressing subtransferable candidate 4
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
  U2 small nuclear RNA auxiliary factor 2
  ubiquitin conjugating enzyme E2 A
  ubiquitin conjugating enzyme E2 B
  ubiquitin conjugating enzyme E2 C
  ubiquitin conjugating enzyme E2 D1
  ubiquitin conjugating enzyme E2 D2
  ubiquitin conjugating enzyme E2 D3
  ubiquitin conjugating enzyme E2 D4 (putative)
  ubiquitin conjugating enzyme E2 E1
  ubiquitin conjugating enzyme E2 E2
  ubiquitin conjugating enzyme E2 E3
  ubiquitin conjugating enzyme E2 G1
  ubiquitin conjugating enzyme E2 G2
  ubiquitin conjugating enzyme E2 H
  ubiquitin conjugating enzyme E2 J1
  ubiquitin conjugating enzyme E2 J2
  ubiquitin conjugating enzyme E2 L3
  ubiquitin conjugating enzyme E2 L6
  ubiquitin conjugating enzyme E2 M
  ubiquitin conjugating enzyme E2 N
  ubiquitin conjugating enzyme E2 Q2
  ubiquitin conjugating enzyme E2 R2
  ubiquitin conjugating enzyme E2 S
  ubiquitin conjugating enzyme E2 T
  ubiquitin conjugating enzyme E2 U
  ubiquitin conjugating enzyme E2 W
  ubiquitin conjugating enzyme E2 Z
  ubiquitin C-terminal hydrolase L3
  ubiquitin D
  ubiquitin domain containing 2
  ubiquitin like modifier activating enzyme 1
  ubiquitin specific peptidase 11
  ubiquitin specific peptidase 14
  ubiquitin specific peptidase 5
  ubiquitin-conjugating enzyme E2K
  ubiquitin-like modifier activating enzyme 1
  unk zinc finger
  USH1 protein network component harmonin
  UV radiation resistance associated
  VHL binding protein 1
  vir like m6A methyltransferase associated
  WD repeat domain 73
  WD repeat domain 76
  WD repeat domain, phosphoinositide interacting 2
  X-prolyl aminopeptidase 1
  Yes1 associated transcriptional regulator

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.