EEF1E1, eukaryotic translation elongation factor 1 epsilon 1

EEF1E1, eukaryotic translation elongation factor 1 epsilon 1

• This gene encodes a multifunctional protein that localizes to both the cytoplasm and nucleus. In the cytoplasm, the encoded protein is an auxiliary component of the macromolecular aminoacyl-tRNA synthase complex. However, its mouse homolog has been shown to translocate to the nucleus in response to DNA damage, and it plays a positive role in ATM/ATR-mediated p53 activation. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream MUTED (muted homolog) gene. An EEF1E1-related pseudogene has been identified on chromosome 2. [provided by RefSeq, Dec 2010]

• Gene Synonyms (eukaryotic translation elongation factor 1 epsilon-1, ARS-interacting multifunctional protein 3, aminoacyl tRNA synthetase complex-interacting multifunctional protein 3, multisynthase complex auxiliary component p18, p18 component of aminoacyl-tRNA synthetase complex, AIMP3, P18,)
• NCBI Gene ID: 9521
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O43324
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

eukaryotic translation elongation factor 1 epsilon 1 interacts with:

• AAR2 splicing factor
  ATPase, Cu++ transporting, alpha polypeptide
  calcium binding and coiled-coil domain 2
  cell cycle and apoptosis regulator 2
  chromosome alignment maintaining phosphoprotein 1
  cytokine induced apoptosis inhibitor 1
  DLG associated protein 4
  egl-9 family hypoxia inducible factor 3
  HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
  HEXIM P-TEFb complex subunit 1
  hypoxia inducible factor 1 subunit alpha inhibitor
  integrin alpha FG-GAP repeat containing 1
  jun B proto-oncogene
  La ribonucleoprotein 7, transcriptional regulator
  leucyl-tRNA synthetase 1
  mab-21 like 2
  mediator complex subunit 4
  methylphosphate capping enzyme
  N-acetyltransferase 9 (putative)
  PIH1 domain containing 1
  pleckstrin homology domain containing A4
  ribonuclease H2 subunit C
  ribosomal protein L36
  serologically defined colon cancer antigen 8
  vir like m6A methyltransferase associated
  WW domain containing E3 ubiquitin protein ligase 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.