SRSF1, serine and arginine rich splicing factor 1

SRSF1, serine and arginine rich splicing factor 1

• This gene encodes a member of the arginine/serine-rich splicing factor protein family. The encoded protein can either activate or repress splicing, depending on its phosphorylation state and its interaction partners. Multiple transcript variants have been found for this gene. There is a pseudogene of this gene on chromosome 13. [provided by RefSeq, Jun 2014]

• Gene Synonyms (serine/arginine-rich splicing factor 1, SR splicing factor 1, alternative-splicing factor 1, pre-mRNA-splicing factor SF2, P33 subunit, splicing factor 2, splicing factor, arginine/serine-rich, 30-KD, A, ASF, SF2, SF2p33, SFRS1, SRp30a,)
• NCBI Gene ID: 6426
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q07955
  UNIPROT ID#>>Q59FA2
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

serine and arginine rich splicing factor 1 interacts with:

• adenosylhomocysteinase like 1
  A-kinase anchoring protein 17A
  Aly/REF export factor
  ariadne RBR E3 ubiquitin protein ligase 2
  BCL10 immune signaling adaptor
  bromodomain containing 7
  BUD13 homolog
  cap methyltransferase 1
  CD2 cytoplasmic tail binding protein 2
  cell division cycle 14A
  COP9 signalosome subunit 5
  corepressor interacting with RBPJ, CIR1
  cullin 1
  cullin 2
  cullin 3
  cullin 4B
  cullin 7
  cullin associated and neddylation dissociated 1
  cyclin dependent kinase 12
  DEAD-box helicase 17
  death inducer-obliterator 1
  developmental pluripotency-associated 3
  DNA topoisomerase I
  elongation factor Tu GTP binding domain containing 2
  embryonic ectoderm development
  eukaryotic translation initiation factor 2 subunit gamma B
  eukaryotic translation initiation factor 4A3
  exportin 1
  expressed sequence AI837181
  Fas associated factor 1
  F-box protein 6
  G1 to S phase transition 2
  GCN1 activator of EIF2AK4
  gem nuclear organelle associated protein 2
  H4 clustered histone 1
  HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
  heterogeneous nuclear ribonucleoprotein A0
  heterogeneous nuclear ribonucleoprotein D like
  heterogeneous nuclear ribonucleoprotein R
  histone deacetylase 5
  homeodomain interacting protein kinase 3
  hyaluronan binding protein 4
  ilvB acetolactate synthase like
  La ribonucleoprotein 7, transcriptional regulator
  leucine zipper protein 4
  ligand of numb-protein X 1
  LUC7 like
  LUC7 like 2, pre-mRNA splicing factor
  LUC7 like 3 pre-mRNA splicing factor
  matrin 3
  mediator of DNA damage checkpoint 1
  methylphosphate capping enzyme
  methyltransferase like 14
  nicastrin
  NKAP domain containing 1
  nuclear receptor subfamily 2 group C member 2
  nuclear RNA export factor 1
  obscurin like cytoskeletal adaptor 1
  PAX interacting protein 1
  PC4 and SFRS1 interacting protein 1
  phosphoglycerate dehydrogenase
  pleckstrin homology domain containing A4
  poly(A) specific ribonuclease subunit PAN2
  pre-mRNA processing factor 19
  pre-mRNA processing factor 4
  pre-mRNA processing factor 4B
  pre-mRNA processing factor 8
  protein inhibitor of activated STAT 1
  RecQ like helicase 4
  regulatory associated protein of MTOR complex 1
  ribosomal RNA processing 1 homolog B (S. cerevisiae)
  ribosomal RNA processing 1B
  ring finger and CCCH-type domains 1
  ring finger and CCCH-type domains 2
  ring finger protein 31
  RIO kinase 1
  RNA binding motif protein 14
  RNA binding motif protein 39
  RNA binding protein with serine rich domain 1
  serine and arginine rich splicing factor 1
  serine and arginine rich splicing factor 10
  serine and arginine rich splicing factor 11
  serine and arginine rich splicing factor 2
  serine and arginine rich splicing factor 3
  serine and arginine rich splicing factor 4
  serine and arginine rich splicing factor 5
  serine and arginine rich splicing factor 6
  serine and arginine rich splicing factor 7
  serine and arginine rich splicing factor 9
  serine hydroxymethyltransferase 2
  serine/arginine repetitive matrix 2
  signal sequence receptor subunit 1
  Sin3A associated protein 18
  Smad nuclear interacting protein 1
  SMAD specific E3 ubiquitin protein ligase 1
  small nuclear ribonucleoprotein polypeptide A'
  small nuclear ribonucleoprotein U1 subunit 70
  small nuclear ribonucleoprotein U5 subunit 200
  SMU1 DNA replication regulator and spliceosomal factor
  snail family transcriptional repressor 1
  SNW domain containing 1
  solute carrier family 30 member 1
  solute carrier family 30 member 5
  spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP
  splicing factor 3a subunit 1
  splicing factor 3a subunit 2
  splicing factor 3b subunit 1
  splicing factor 3b subunit 3
  splicing regulatory glutamic acid and lysine rich protein 1
  sprouty-related EVH1 domain containing 2
  SprT-like N-terminal domain
  SR-related CTD associated factor 11
  SRSF protein kinase 1
  SRSF protein kinase 2
  SRSF protein kinase 3
  staufen double-stranded RNA binding protein 1
  SUB1 regulator of transcription
  surfeit 4
  SUZ12 polycomb repressive complex 2 subunit
  SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
  synaptosome associated protein 23
  synaptotagmin binding cytoplasmic RNA interacting protein
  TATA-box binding protein associated factor 15
  thymopoietin
  TNF receptor associated factor 2
  TNF receptor associated factor 5
  TNFAIP3 interacting protein 2
  TRAF3 interacting protein 2
  transcription elongation regulator 1
  transcriptional adaptor 2A
  transformer 2 beta homolog
  translocase of outer mitochondrial membrane 20
  transmembrane protein 43
  transportin 3
  tripartite motif containing 55
  tRNA methyltransferase subunit 11-2
  tumor protein p53
  tumor protein p53 binding protein 1
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
  U2 small nuclear RNA auxiliary factor 1
  U2 small nuclear RNA auxiliary factor 2
  ubiquitin C
  ubiquitin conjugating enzyme E2 I
  ubiquitin protein ligase E3 component n-recognin 5
  UTP14A small subunit processome component
  vasorin
  vitronectin
  WD repeat domain 18
  WW domain containing E3 ubiquitin protein ligase 2
  X-box binding protein 1
  YTH domain containing 1
  zinc finger and BTB domain containing 1
  zinc finger CCCH-type containing 18
  zinc finger CCCH-type containing 3
  zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2
  zinc finger MYND-type containing 11
  zinc finger protein 326
  zinc finger protein 746

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.