TRAF5, TNF receptor associated factor 5

TRAF5, TNF receptor associated factor 5

• The scaffold protein encoded by this gene is a member of the tumor necrosis factor receptor-associated factor (TRAF) protein family and contains a meprin and TRAF homology (MATH) domain, a RING-type zinc finger, and two TRAF-type zinc fingers. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. This protein is one of the components of a multiple protein complex which binds to tumor necrosis factor (TNF) receptor cytoplasmic domains and mediates TNF-induced activation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]

• Gene Synonyms (TNF receptor-associated factor 5, RING finger protein 84, MGC:39780, RNF84,)
• NCBI Gene ID: 7188
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O00463
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

TNF receptor associated factor 5 interacts with:

• brain expressed X-linked 3
  calcium and integrin binding family member 3
  cell division cycle 37, HSP90 cochaperone
  coiled-coil domain containing 184
  coiled-coil domain containing 40
  COMM domain containing 3
  component of oligomeric golgi complex 5
  component of oligomeric golgi complex 7
  DExH-box helicase 58
  diacylglycerol kinase eta
  ecto-NOX disulfide-thiol exchanger 2
  family with sequence similarity 9 member A
  F-box protein 28
  golgi reassembly stacking protein 2
  heat shock transcription factor 2 binding protein
  homer scaffold protein 1
  leucine zipper tumor suppressor 2
  ligand of numb-protein X 1
  LIM domain only 4
  mitochondrial antiviral signaling protein
  mitogen-activated protein kinase kinase kinase 14
  N-myc and STAT interactor
  N-terminal glutamine amidase 1
  nuclear factor of activated T cells 2 interacting protein
  NUMB like endocytic adaptor protein
  progesterone immunomodulatory binding factor 1
  protein inhibitor of activated STAT 2
  protein interacting with PRKCA 1
  receptor interacting serine/threonine kinase 1
  receptor interacting serine/threonine kinase 2
  ring finger protein 111
  serine and arginine-rich splicing factor 1
  SMAD specific E3 ubiquitin protein ligase 1
  small ubiquitin like modifier 1
  TANK binding kinase 1
  THAP domain containing 1
  THAP domain containing 7
  TNF receptor associated factor 5
  TNF receptor associated factor 6
  TNF receptor superfamily member 11a
  TNF receptor superfamily member 12A
  TNF receptor superfamily member 13B
  TNF receptor superfamily member 14
  TNF receptor superfamily member 19
  TNF receptor superfamily member 4
  toll like receptor adaptor molecule 1
  TRAF family member associated NFKB activator
  TRAF interacting protein
  TRAF3 interacting protein 2
  tripartite motif containing 8
  tumor necrosis factor receptor superfamily, member 12a
  tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)
  tyrosyl-DNA phosphodiesterase 2
  ubiquitin C
  ubiquitin conjugating enzyme E2 O
  ubiquitin specific peptidase 7
  yippee like 5
  zinc finger AN1-type containing 6
  zinc finger MYND-type containing 11
  zinc finger protein 655

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.