GEMIN2, gem nuclear organelle associated protein 2

GEMIN2, gem nuclear organelle associated protein 2

• This gene encodes one of the proteins found in the SMN complex, which consists of several gemin proteins and the protein known as the survival of motor neuron protein. The SMN complex is localized to a subnuclear compartment called gems (gemini of coiled bodies) and is required for assembly of spliceosomal snRNPs and for pre-mRNA splicing. This protein interacts directly with the survival of motor neuron protein and it is required for formation of the SMN complex. A knockout mouse targeting the mouse homolog of this gene exhibited disrupted snRNP assembly and motor neuron degeneration. [provided by RefSeq, Aug 2011]

• Gene Synonyms (gem-associated protein 2, SMN interacting protein 1-delta, component of gems 2, gemin-2, survival of motor neuron protein interacting protein 1, SIP1, SIP1-delta,)
• NCBI Gene ID: 8487
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O14893
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

gem nuclear organelle associated protein 2 interacts with:

• actin beta like 2
  ankyrin repeat domain 26
  B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB
  BEN domain containing 7
  catechol-O-methyltransferase domain containing 1
  centrosomal AT-AC splicing factor
  ceramide kinase
  chaperonin containing Tcp1, subunit 4 (delta)
  coiled-coil domain containing 8
  DEAD-box helicase 20
  developmental pluripotency-associated 3
  egl-9 family hypoxia inducible factor 3
  erythroblast membrane associated protein (Scianna blood group)
  F-box protein 7
  GAR1 ribonucleoprotein
  gem nuclear organelle associated protein 2
  gem nuclear organelle associated protein 4
  gem nuclear organelle associated protein 5
  gem nuclear organelle associated protein 6
  gem nuclear organelle associated protein 7
  gem nuclear organelle associated protein 8
  histone deacetylase 11
  inhibitor of CDK, cyclin A1 interacting protein 1
  inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
  IQ motif containing B1
  karyopherin subunit alpha 6
  LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated
  MMS19 homolog, cytosolic iron-sulfur assembly component
  NCK interacting protein with SH3 domain
  NDC80 kinetochore complex component
  NLR family pyrin domain containing 3
  nuclear FMR1 interacting protein 1
  pleckstrin homology domain containing A4
  PNKD metallo-beta-lactamase domain containing
  protein kinase AMP-activated non-catalytic subunit gamma 2
  RAD50 double strand break repair protein
  regulator of chromosome condensation 1
  ribonuclease P/MRP subunit p14
  RNA binding protein with serine rich domain 1
  RNA polymerase III subunit B
  serine/threonine kinase receptor associated protein
  SIGLEC family like 1
  small nuclear ribonucleoprotein 70 (U1)
  SPG21 abhydrolase domain containing, maspardin
  striatin 4
  survival motor neuron 1
  tubulin, gamma 1
  U2 small nuclear RNA auxiliary factor 2
  ubiquitin like modifier activating enzyme 2
  yes-associated protein 1
  zinc finger CCHC-type containing 9

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.