PSMA6, proteasome 20S subunit alpha 6

PSMA6, proteasome 20S subunit alpha 6

• The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Multiple transcript variants encoding several different isoforms have been found for this gene. A pseudogene has been identified on the Y chromosome. [provided by RefSeq, Aug 2013]

• Gene Synonyms (proteasome subunit alpha type-6, 27 kDa prosomal protein, PROS-27, macropain iota chain, macropain subunit iota, multicatalytic endopeptidase complex iota chain, prosomal P27K protein, proteasome (prosome, macropain) subunit, alpha type, 6, proteasome iota chain, proteasome subunit alpha 6, proteasome subunit alpha1, proteasome subunit iota, testicular secretory protein Li 44, IOTA, PROS27, p27K,)
• NCBI Gene ID: 5687
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P60900
  UNIPROT ID#>>A0A140VK44
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

proteasome 20S subunit alpha 6 interacts with:

• adhesion regulating molecule 1
  alkB homolog 4, lysine demethylase
  anterior gradient 2, protein disulphide isomerase family member
  aurora kinase A
  autophagy and beclin 1 regulator 1
  autophagy related 16 like 1
  BAG cochaperone 3
  cell adhesion molecule 1
  centrosomal protein 85
  chaperonin containing TCP1 subunit 3
  chaperonin containing TCP1 subunit 4
  chaperonin containing TCP1 subunit 5
  chaperonin containing TCP1 subunit 8
  chromosome 19 open reading frame 47
  chromosome 19 open reading frame 57
  COP9 signalosome subunit 2
  COP9 signalosome subunit 5
  cullin 1
  cullin associated and neddylation dissociated 2 (putative)
  derlin 1
  desumoylating isopeptidase 1
  DnaJ heat shock protein family (Hsp40) member A2
  Ecm29 proteasome adaptor and scaffold
  elongator acetyltransferase complex subunit 6
  exosome component 4
  exosome component 5
  exosome component 6
  F-box and WD repeat domain containing 7
  F-box protein 7
  FKBP prolyl isomerase 8
  HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
  HEXIM P-TEFb complex subunit 1
  IQ motif containing B1
  ISY1 splicing factor homolog
  ISY1-RAB43 readthrough
  keratin associated protein 4-2
  La ribonucleoprotein 7, transcriptional regulator
  leucine rich repeat kinase 2
  LIM domain containing 2
  methylphosphate capping enzyme
  microtubule associated protein 1 light chain 3 beta
  negative elongation factor complex member E
  NHL repeat containing 2
  nuclear receptor subfamily 2 group C member 2
  patched 1
  PAX interacting protein 1
  pleckstrin homology domain containing A4
  proteasome (prosome, macropain) subunit, beta type 4
  proteasome (prosome, macropain) subunit, beta type 5
  proteasome 20S subunit alpha 6
  proteasome 20S subunit alpha 7
  proteasome 20S subunit alpha 8
  proteasome 20S subunit beta 1
  proteasome 20S subunit beta 2
  proteasome 20S subunit beta 3
  proteasome 20S subunit beta 4
  proteasome 20S subunit beta 5
  proteasome 20S subunit beta 6
  proteasome 20S subunit beta 7
  proteasome 20S subunit beta 8
  proteasome 20S subunit beta 9
  proteasome 26S subunit, ATPase 1
  proteasome 26S subunit, ATPase 2
  proteasome 26S subunit, ATPase 3
  proteasome 26S subunit, ATPase 4
  proteasome 26S subunit, ATPase 5
  proteasome 26S subunit, ATPase 6
  proteasome 26S subunit, non-ATPase 1
  proteasome 26S subunit, non-ATPase 11
  proteasome 26S subunit, non-ATPase 12
  proteasome 26S subunit, non-ATPase 13
  proteasome 26S subunit, non-ATPase 14
  proteasome 26S subunit, non-ATPase 2
  proteasome 26S subunit, non-ATPase 3
  proteasome 26S subunit, non-ATPase 4
  proteasome 26S subunit, non-ATPase 5
  proteasome 26S subunit, non-ATPase 6
  proteasome 26S subunit, non-ATPase 7
  proteasome 26S subunit, non-ATPase 8
  proteasome activator subunit 1
  proteasome activator subunit 2
  proteasome activator subunit 3
  proteasome assembly chaperone 1
  proteasome assembly chaperone 2
  proteasome assembly chaperone 3
  proteasome maturation protein
  protein tyrosine phosphatase non-receptor type 11
  protein tyrosine phosphatase non-receptor type 2
  pyrroline-5-carboxylate reductase 3
  RAD23 homolog A, nucleotide excision repair protein
  receptor transporter protein 5 (putative)
  RecQ like helicase 4
  ribonuclease P/MRP subunit p30
  ribonuclease P/MRP subunit p38
  ring finger protein 170
  ring finger protein 185
  ring finger protein 2
  ring-box 1
  SEM1 26S proteasome complex subunit
  sequestosome 1
  SHANK associated RH domain interactor
  signal regulatory protein alpha
  single-pass membrane protein with coiled-coil domains 3
  SLX1 homolog B, structure-specific endonuclease subunit
  small nuclear ribonucleoprotein polypeptide A'
  S-phase kinase associated protein 1
  S-phase kinase-associated protein 1
  splicing factor 3a subunit 1
  superoxide dismutase 1
  synoviolin 1
  TAR DNA binding protein
  TEPSIN adaptor related protein complex 4 accessory protein
  thioredoxin like 1
  TNFAIP3 interacting protein 2
  tripartite motif containing 39
  tropomyosin 3
  tropomyosin 4
  TSPY like 1
  ubiquilin 1
  ubiquilin 2
  ubiquilin 4
  ubiquitin C
  ubiquitin conjugating enzyme E2 M
  ubiquitin C-terminal hydrolase L5
  ubiquitin D
  ubiquitin protein ligase E3A
  ubiquitin specific peptidase 14
  ubiquitin specific peptidase 4
  ubiquitin specific peptidase 53
  UBX domain protein 4
  valosin containing protein
  vascular cell adhesion molecule 1
  vir like m6A methyltransferase associated
  WD repeat domain 11
  X-box binding protein 1
  zinc finger and BTB domain containing 44
  zinc finger protein 596
  zinc finger protein 598, E3 ubiquitin ligase
  zinc finger with KRAB and SCAN domains 4

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.