TRADD, TNFRSF1A associated via death domain

TRADD, TNFRSF1A associated via death domain

• The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-kappaB activation. This protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway. [provided by RefSeq, Jul 2008]

• Gene Synonyms (tumor necrosis factor receptor type 1-associated DEATH domain protein, TNFR1-associated death domain protein, tumor necrosis factor receptor type 1 associated death domain protein, tumor necrosis factor receptor-1-associated protein, Hs.89862,)
• NCBI Gene ID: 8717
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q15628
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

TNFRSF1A associated via death domain interacts with:

• 3'(2'), 5'-bisphosphate nucleotidase 1
  ANTXR cell adhesion molecule 1
  BCL10 immune signaling adaptor
  C1q and TNF related 3
  carbohydrate sulfotransferase 12
  cell cycle and apoptosis regulator 2
  centriolin
  chondroitin polymerizing factor
  Coenzyme A synthase
  DAB2 interacting protein
  DENN domain containing 5A
  dihydrouridine synthase 3 like
  ectodysplasin A receptor
  Fas associated via death domain
  G3BP stress granule assembly factor 1
  HECT and RLD domain containing E3 ubiquitin protein ligase 4
  heterogeneous nuclear ribonucleoprotein C like 2
  homeodomain interacting protein kinase 2
  hyaluronan and proteoglycan link protein 3
  leucine rich repeat kinase 2
  MINDY lysine 48 deubiquitinase 3
  mitotic arrest deficient 2 like 2
  NEDD1 gamma-tubulin ring complex targeting factor
  neural precursor cell expressed, developmentally down-regulated gene 1
  neuroligin 1
  nucleolar protein 3
  nucleolar protein 6
  nucleoporin 85
  optineurin
  PDZ and LIM domain 7
  peroxisome proliferator activated receptor gamma
  podoplanin
  pre-mRNA processing factor 4
  procollagen C-endopeptidase enhancer 2
  receptor interacting serine/threonine kinase 1
  regulator of chromosome condensation 2
  riboflavin kinase
  ribosomal RNA processing 9, U3 small nucleolar RNA binding protein
  ring finger protein 115
  RNA polymerase I subunit A
  SH3 domain containing kinase binding protein 1
  spermatogenesis associated 2
  sphingosine-1-phosphate receptor 2
  teneurin transmembrane protein 3
  THAP domain containing 4
  THO complex 2
  thyroid hormone receptor interactor 12
  TNF receptor superfamily member 10a
  TNF receptor superfamily member 10b
  TNF receptor superfamily member 21
  TNF receptor superfamily member 25
  TNFAIP3 interacting protein 1
  TNFRSF1A associated via death domain
  transient receptor potential cation channel subfamily C member 4 associated protein
  translocase of outer mitochondrial membrane 70
  transmembrane channel like 8
  tumor necrosis factor receptor superfamily, member 1a
  ubiquitin specific peptidase 2
  UEV and lactate/malate dehyrogenase domains
  unc-51 like kinase 3
  zinc finger MYND-type containing 11

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.