RBM8A, RNA binding motif protein 8A

RBM8A, RNA binding motif protein 8A

• This gene encodes a protein with a conserved RNA-binding motif. The protein is found predominantly in the nucleus, although it is also present in the cytoplasm. It is preferentially associated with mRNAs produced by splicing, including both nuclear mRNAs and newly exported cytoplasmic mRNAs. It is thought that the protein remains associated with spliced mRNAs as a tag to indicate where introns had been present, thus coupling pre- and post-mRNA splicing events. Previously, it was thought that two genes encode this protein, RBM8A and RBM8B; it is now thought that the RBM8B locus is a pseudogene. There are two alternate translation start codons with this gene, which result in two forms of the protein. An allele mutation and a low-frequency noncoding single-nucleotide polymorphism (SNP) in this gene cause thrombocytopenia-absent radius (TAR) syndrome. [provided by RefSeq, Jul 2013]

• Gene Synonyms (RNA-binding protein 8A, BOV-1, RNA binding motif protein 8B, RNA-binding protein Y14, binder of OVCA1, binder of OVCA1-1, ribonucleoprotein RBM8, ribonucleoprotein RBM8A, BOV-1A, BOV-1B, BOV-1C, C1DELq21.1, DEL1q21.1, MDS014, RBM8, RBM8B, TAR, Y14, ZNRP, ZRNP1,)
• NCBI Gene ID: 9939
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A023T787
  UNIPROT ID#>>Q9Y5S9
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

RNA binding motif protein 8A interacts with:

• Aly/REF export factor
  anterior gradient 2, protein disulphide isomerase family member
  aprataxin
  B cell receptor associated protein 31
  CASC3 exon junction complex subunit
  coiled-coil domain containing 9
  cytokine induced apoptosis inhibitor 1
  dynamin 1 like
  EH domain binding protein 1 like 1
  F-box protein 25
  leucine zipper protein 4
  LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated
  LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated
  LUC7 like 2, pre-mRNA splicing factor
  mago homolog B, exon junction complex subunit
  mago homolog, exon junction complex core component
  NCBP2 antisense 2 (head to head)
  non-SMC condensin II complex subunit H2
  NOP9 nucleolar protein
  nuclear cap binding protein subunit 2
  nuclear RNA export factor 1
  obscurin like cytoskeletal adaptor 1
  PDGFA associated protein 1
  plakophilin 3
  poly(A) binding protein cytoplasmic 1
  prolyl 3-hydroxylase 1
  pseudouridine synthase 7
  PYM homolog 1, exon junction complex associated factor
  R3H domain and coiled-coil containing 1 like
  RAD18 E3 ubiquitin protein ligase
  RNA binding motif protein 14
  RNA binding motif protein 8A
  RNA binding motif protein X-linked
  RNA binding protein with serine rich domain 1
  RPGR interacting protein 1
  RuvB like AAA ATPase 2
  SDE2 telomere maintenance homolog
  selenophosphate synthetase 2
  serine and arginine repetitive matrix 1
  serine/arginine repetitive matrix 2
  SLU7 homolog, splicing factor
  SMG1 nonsense mediated mRNA decay associated PI3K related kinase
  SMG5 nonsense mediated mRNA decay factor
  SMG6 nonsense mediated mRNA decay factor
  SMG8 nonsense mediated mRNA decay factor
  SMG9 nonsense mediated mRNA decay factor
  splicing factor 3b subunit 2
  SRA stem-loop interacting RNA binding protein
  SUZ12 polycomb repressive complex 2 subunit
  target of EGR1, exonuclease
  THO complex 7
  TNFAIP3 interacting protein 2
  transcription factor CP2 like 1
  transmembrane protein 263
  tudor domain containing 3
  ubiquitin specific peptidase 21
  unc-119 lipid binding chaperone B
  UPF2 regulator of nonsense mediated mRNA decay
  UPF3A regulator of nonsense mediated mRNA decay
  UPF3B regulator of nonsense mediated mRNA decay
  zinc finger MYND-type containing 8

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.