UPF3A, UPF3A regulator of nonsense mediated mRNA decay

UPF3A, UPF3A regulator of nonsense mediated mRNA decay

• This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome 13. Several splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2017]

• Gene Synonyms (regulator of nonsense transcripts 3A, UPF3 regulator of nonsense transcripts homolog A, hUpf3, nonsense mRNA reducing factor 3A, up-frameshift suppressor 3 homolog A, HUPF3A, RENT3A, UPF3,)
• NCBI Gene ID: 65110
• Species: Homo sapiens (Human)
• UNIPROT ID#>>B3KUE7
  UNIPROT ID#>>Q9H1J1
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

UPF3A regulator of nonsense mediated mRNA decay interacts with:

• CDK5 regulatory subunit associated protein 3
  decapping mRNA 2

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