HAP1, huntingtin associated protein 1

HAP1, huntingtin associated protein 1

• Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with huntingtin, with two cytoskeletal proteins (dynactin and pericentriolar autoantigen protein 1), and with a hepatocyte growth factor-regulated tyrosine kinase substrate. The interactions with cytoskeletal proteins and a kinase substrate suggest a role for this protein in vesicular trafficking or organelle transport. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

• Gene Synonyms (huntingtin-associated protein 1, HAP-1, epididymis secretory sperm binding protein, huntingtin-associated protein 2, neuroan 1, HAP2, HIP5, HLP, hHLP1,)
• NCBI Gene ID: 9001
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P54257
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

huntingtin associated protein 1 interacts with:

• adenine nucleotide translocase lysine methyltransferase
  apoptosis enhancing nuclease
  ATP synthase membrane subunit f
  bromodomain containing 7
  C2 calcium dependent domain containing 6
  CDK5 regulatory subunit associated protein 2
  cell division cycle 73
  chromobox 8
  chromosome 1 open reading frame 216
  chromosome 7 open reading frame 25
  chromosome 8 open reading frame 33
  coiled-coil domain containing 113
  coiled-coil domain containing 13
  DEAD-box helicase 49
  family with sequence similarity 50 member B
  fasciculation and elongation protein zeta 1
  G protein-coupled receptor associated sorting protein 2
  GABA type A receptor associated protein like 2
  GIT ArfGAP 1
  growth arrest and DNA damage inducible gamma
  hepatocyte growth factor-regulated tyrosine kinase substrate
  histone deacetylase 4
  huntingtin associated protein 1
  inhibitor of growth family member 5
  inner membrane mitochondrial protein
  katanin regulatory subunit B1 like 1
  kelch repeat and BTB domain containing 7
  ligand dependent nuclear receptor interacting factor 1
  LUC7 like 2, pre-mRNA splicing factor
  lysine acetyltransferase 5
  lysine acetyltransferase 7
  mesogenin 1
  mitochondrial ribosomal protein S9
  nipsnap homolog 3A
  NOP53 ribosome biogenesis factor
  nucleosome assembly protein 1 like 5
  nucleotide binding oligomerization domain containing 2
  polynucleotide kinase 3'-phosphatase
  pre-mRNA processing factor 31
  programmed cell death 7
  protein phosphatase 1 regulatory subunit 18
  replication timing regulatory factor 1
  retention in endoplasmic reticulum sorting receptor 1
  rhophilin Rho GTPase binding protein 1
  SNAP associated protein
  sodium channel modifier 1
  TATA-box binding protein associated factor, RNA polymerase I subunit D
  translocase of inner mitochondrial membrane 17A
  translocase of outer mitochondrial membrane 20
  UTP3 small subunit processome component
  ZFP1 zinc finger protein
  zinc finger matrin-type 2
  zinc finger protein 490
  zinc finger protein 572
  zinc finger protein 575
  zinc finger protein 648
  zinc finger protein 691
  zinc finger protein 835

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.