TAP1, transporter 1, ATP binding cassette subfamily B member

TAP1, transporter 1, ATP binding cassette subfamily B member

• The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is involved in the pumping of degraded cytosolic peptides across the endoplasmic reticulum into the membrane-bound compartment where class I molecules assemble. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]

• Gene Synonyms (antigen peptide transporter 1, ABC transporter, MHC 1, ATP-binding cassette sub-family B member 2, ATP-binding cassette, sub-family B (MDR/TAP), member 2, peptide supply factor 1, peptide transporter PSF1, peptide transporter TAP1, peptide transporter involved in antigen processing 1, really interesting new gene 4 protein, transporter 1 ATP-binding cassette sub-family B, transporter 1, ATP-binding cassette, sub-family B (MDR/TAP), transporter associated with antigen processing, transporter, ATP-binding cassette, major histocompatibility complex, 1, ABC17, ABCB2, APT1, D6S114E, PSF-1, PSF1, RING4, TAP1*0102N, TAP1N,)
• NCBI Gene ID: 6890
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A0S2Z5A6
  UNIPROT ID#>>Q03518
  UNIPROT ID#>>B7Z7P4
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

transporter 1, ATP binding cassette subfamily B member interacts with:

• androgen receptor
  atlastin GTPase 3
  bone morphogenetic protein receptor, type 1A
  cAMP responsive element binding protein 3
  coiled-coil domain containing 8
  COPI coat complex subunit gamma 1
  cytochrome b5 type B
  endogenous retrovirus group FRD member 1, envelope
  ERGIC and golgi 3
  G protein-coupled receptor 152
  GADD45G interacting protein 1
  gem nuclear organelle associated protein 4
  keratin associated protein 4-12
  late cornified envelope 2C
  listerin E3 ubiquitin protein ligase 1
  malonyl-CoA-acyl carrier protein transacylase
  membrane bound O-acyltransferase domain containing 1
  mitochondrial E3 ubiquitin protein ligase 1
  mitochondrial ribosomal protein L40
  pleckstrin homology domain containing A4
  protein disulfide isomerase family A member 2
  RAB5C, member RAS oncogene family
  retinol dehydrogenase 11
  ring finger protein 19B
  serine rich single-pass membrane protein 1
  SID1 transmembrane family, member 2
  sideroflexin 1
  solute carrier family 10 member 6
  solute carrier family 33 member 1
  solute carrier family 35 member C2
  TAP binding protein
  tectonic family member 3
  translocase of outer mitochondrial membrane 40
  transmembrane p24 trafficking protein 2
  transmembrane protein 14B
  transmembrane protein 63B
  transporter 2, ATP binding cassette subfamily B member
  trinucleotide repeat containing adaptor 6A
  tubulin, gamma complex associated protein 5
  tyrosyl-DNA phosphodiesterase 2
  VAMP associated protein A
  vir like m6A methyltransferase associated
  voltage dependent anion channel 2
  X-ray repair cross complementing 3

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.